Foxa3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxa3
forkhead box A3
MGI:1347477

23 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxa3^tm1Khk/Foxa3^tm1Khk B6.129P2-Foxa3^tm1Khk	abnormal beige fat cell morphology	J:216477
	abnormal lipid homeostasis	J:216477
	abnormal primordial germ cell proliferation	J:134427
	abnormal seminiferous tubule epithelium morphology	J:134427
	abnormal Sertoli cell morphology	J:134427
	abnormal spermatogenesis	J:134427
	decreased body fat mass	J:216477
	decreased brown fat cell size	J:216477
	decreased circulating cholesterol level	J:216477
	decreased circulating leptin level	J:216477
	decreased fasting circulating glucose level	J:72595
	decreased hepatic glucose production	J:72595
	decreased susceptibility to weight gain	J:216477
	decreased testis weight	J:134427
	decreased white fat cell size	J:216477
	extended life span	J:216477
	increased adipocyte glucose uptake	J:216477
	increased insulin sensitivity	J:216477
	increased male germ cell apoptosis	J:134427
	increased oxygen consumption	J:216477
	reduced male fertility	J:134427
	seminiferous tubule degeneration	J:134427
Foxa3^tm1Khk/Foxa3^tm1Khk involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:48310

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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