Foxc2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxc2
forkhead box C2
MGI:1347481

102 phenotypes from 5 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxc2^tm1.1Miu/Foxc2^tm1.1Miu Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	normal craniofacial phenotype	J:316530
	interrupted aortic arch, type b	J:316530
	neonatal lethality, complete penetrance	J:316530
	perimembraneous ventricular septal defect	J:316530
	normal skeleton phenotype	J:316530
Foxc2^tm1.1Miu/Foxc2^tm1.1Miu Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * C57BL/6J * SJL	abnormal lymphatic vessel morphology	J:316530
	normal cardiovascular system phenotype	J:316530
	normal craniofacial phenotype	J:316530
	lymphedema	J:316530
	neonatal lethality, complete penetrance	J:316530
	pericardial effusion	J:316530
	normal skeleton phenotype	J:316530
Foxc2^tm1.1Tsku/Foxc2^tm1.1Tsku involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL	no abnormal phenotype detected	J:188816
Foxc2^tm1.2Tsku/Foxc2^tm1.2Tsku involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS	thin myocardium	J:188816
	ventricular septal defect	J:188816
Foxc2^tm1Blh/Foxc2⁺ involves: 129S6/SvEvTac * Black Swiss	abnormal canal of Schlemm morphology	J:61775
	abnormal iridocorneal angle	J:61775
	abnormal iris morphology	J:61775
	abnormal iris pigment epithelium	J:61775
	abnormal trabecular meshwork morphology	J:61775
	iris stroma hypoplasia	J:61775
Foxc2^tm1Blh/Foxc2^tm1Blh involves: 129S6/SvEvTac	abnormal somite shape	J:91443
Foxc2^tm1Blh/Foxc2^tm1Blh involves: 129S6/SvEvTac * Black Swiss	abnormal blood vessel morphology	J:39636
	abnormal cartilage morphology	J:39636
	abnormal gonial bone morphology	J:39636
	abnormal malleus morphology	J:39636
	abnormal Meckel's cartilage morphology	J:39636
	abnormal middle ear ossicle morphology	J:39636
	abnormal multipotent stem cell morphology	J:39636
	abnormal somite shape	J:39636
	abnormal vertebral arch morphology	J:39636
	abnormal vertebral body morphology	J:39636
	absent incus	J:39636
	absent palatine bone	J:39636
	absent palatine bone horizontal plate	J:39636
	absent presphenoid bone	J:39636
	absent stapes	J:39636
	absent supraoccipital bone	J:39636
	cleft palate	J:39636
	decreased rib number	J:39636
	decreased tympanic ring size	J:39636
	embryonic lethality during organogenesis, incomplete penetrance	J:39636
	intracranial hemorrhage	J:39636
	kinked neural tube	J:39636
	rib fusion	J:39636
	small basioccipital bone	J:39636
	small exoccipital bone	J:39636
	small interparietal bone	J:39636
	small kidney	J:60834
	small mandible	J:39636
	small Meckel's cartilage	J:39636
	small pterygoid bone	J:39636
	small temporal bone squamous part	J:39636
	spinal hemorrhage	J:39636
Foxc2^tm1Miu/Foxc2⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	abnormal eye morphology	J:83436
	abnormal lymph circulation	J:83436
	abnormal orbit morphology	J:83436
	abnormal thoracic duct morphology	J:83436
	blepharoptosis	J:83436
	cataract	J:83436
	cornea abrasion	J:83436
	enlarged lymph nodes	J:83436
	extremity edema	J:83436
	eye opacity	J:83436
	increased brown adipose tissue amount	J:83436
	increased lymph node number	J:83436
	lymphangiectasis	J:83436
	lymphatic vessel hyperplasia	J:83436
	lymphedema	J:83436
	ocular distichiasis	J:83436
	periorbital edema	J:83436
Foxc2^tm1Miu/Foxc2^tm1Miu involves: 129P2/OlaHsd * C57BL/6	abnormal alisphenoid bone morphology	J:55316
	abnormal aortic arch morphology	J:55316
	abnormal basisphenoid bone morphology	J:55316
	abnormal bone ossification	J:55316
	abnormal craniofacial bone morphology	J:55316
	abnormal fourth pharyngeal arch artery morphology	J:55316
	abnormal malleus morphology	J:55316
	abnormal middle ear ossicle morphology	J:55316
	abnormal otic vesicle development	J:55316
	abnormal palatine bone horizontal plate morphology	J:55316
	abnormal presphenoid bone morphology	J:55316
	abnormal pterygoid process morphology	J:55316
	abnormal sphenoid bone morphology	J:55316
	abnormal supraoccipital bone morphology	J:55316
	abnormal third pharyngeal arch artery morphology	J:55316
	abnormal vertebral arch morphology	J:55575
	abnormal vertebral body morphology	J:55316, J:55575
	absent cartilage	J:55316
	absent soft palate	J:55316
	aortic arch coarctation	J:55316
	atelectasis	J:55316
	cleft secondary palate	J:55316
	embryonic lethality during organogenesis, incomplete penetrance	J:55316
	gonial bone hypoplasia	J:55316
	interrupted aortic arch, type b	J:55316
	malleus hypoplasia	J:55316
	perinatal lethality, complete penetrance	J:55316
	rib fusion	J:55575
	short vertebral body	J:55316
	small vertebral body	J:55575
	spina bifida occulta	J:55316
	ventricular septal defect	J:55316
Foxc2^tm1Miu/Foxc2^tm1Miu involves: 129P2/OlaHsd * C57BL/6J * ICR	abnormal glomerular mesangium morphology	J:106710
	abnormal mesangial cell morphology	J:106710
	abnormal podocyte morphology	J:106710
	abnormal renal glomerulus basement membrane morphology	J:106710
	abnormal renal glomerulus morphology	J:106710
	absent glomerular endothelium fenestra	J:106710
	absent podocyte foot process	J:106710
	absent podocyte slit diaphragm	J:106710
	decreased glomerular capillary number	J:106710
	decreased renal glomerulus number	J:106710
	dilated glomerular capillary	J:106710
	glomerulus hemorrhage	J:106710
	small kidney	J:106710

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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