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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cops5
COP9 signalosome subunit 5
MGI:1349415
39 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cops5tm1Fxc/Cops5+
involves: 129S7/SvEvBrd * C57BL/6J 		decreased cell proliferation J:166561
Cops5tm1Fxc/Cops5tm1Fxc
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal DNA repair J:166561
abnormal egg cylinder morphology J:166561
abnormal inner cell mass apoptosis J:166561
decreased embryo size J:166561
decreased inner cell mass proliferation J:166561
embryonic growth retardation J:166561
embryonic lethality between implantation and somite formation, complete penetrance J:166561
increased embryonic tissue cell apoptosis J:166561
spontaneous chromosome breakage J:166561
Cops5tm1Jka/Cops5+
involves: 129S4/SvJae * C57BL/6 		decreased body size J:93979
decreased body weight J:93979
Cops5tm1Jka/Cops5tm1Jka
involves: 129S4/SvJae * C57BL/6 		abnormal trophoblast giant cell proliferation J:93979
absent inner cell mass proliferation J:93979
decreased embryo size J:93979
embryonic growth arrest J:93979
embryonic lethality between implantation and somite formation, complete penetrance J:93979
failure to gastrulate J:93979
inner cell mass degeneration J:93979
Cops5tm1Rpar/Cops5tm1Rpar
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:132114
Cops5tm1Rpar/Cops5tm1Rpar
Tg(Lck-cre)548Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL 		abnormal cell cycle checkpoint function J:132114
decreased double-positive T cell number J:132114
decreased single-positive T cell number J:132114
decreased thymocyte number J:132114
increased T cell apoptosis J:132114
thymus medulla hypoplasia J:132114
Cops5tm1Rpar/Cops5tm1Rpar
Tg(Stra8-icre)1Reb/0
involves: 129 * C57BL/6 * FVB/NJ * SJL 		abnormal acrosome assembly J:307573
abnormal ectoplasmic specialization morphology J:307573
abnormal seminiferous tubule epithelium morphology J:307573
abnormal seminiferous tubule morphology J:307573
abnormal sperm nucleus morphology J:307573
abnormal spermatid morphology J:307573
abnormal spermatogenesis J:307573
asthenozoospermia J:307573
decreased testis weight J:307573
immotile sperm J:307573
increased male germ cell apoptosis J:307573
male infertility J:307573
oligozoospermia J:307573
small testis J:307573
teratozoospermia J:307573
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory