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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Exo1
exonuclease 1
MGI:1349427
29 phenotypes from 3 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Exo1tm1Wed/Exo1tm1Wed
involves: 129/Sv * C57BL/6J * SJL 		abnormal chiasmata formation J:82426
abnormal male meiosis J:82426
abnormal meiotic configurations J:82426
abnormal meiotic spindle morphology J:82426
abnormal mismatch repair J:82426
abnormal ovary morphology J:82426
absent chiasmata formation J:82426
asthenozoospermia J:82426
chromosomal instability J:82426
decreased oocyte number J:82426
female infertility J:82426
increased lymphoma incidence J:82426
increased male germ cell apoptosis J:82426
increased tumor incidence J:82426
male infertility J:82426
oligozoospermia J:82426
premature death J:82426
small ovary J:82426
small testis J:82426
Exo1tm2Wed/Exo1tm2Wed
involves: 129 * C57BL/6 		abnormal class switch recombination J:198719
abnormal double-strand DNA break repair J:198719
abnormal male germ cell apoptosis J:198719
abnormal male meiosis J:198719
abnormal mismatch repair J:198719
abnormal somatic hypermutation frequency J:198719
decreased testis weight J:198719
increased adenoma incidence J:198719
increased lymphoma incidence J:198719
increased sarcoma incidence J:198719
increased tumor incidence J:198719
oligozoospermia J:198719
premature death J:198719
normal reproductive system phenotype J:198719
small testis J:198719
Exo1tm3.1Wed/Exo1tm3.1Wed
involves: 129 * C57BL/6 		abnormal double-strand DNA break repair J:198719
normal homeostasis/metabolism phenotype J:198719
normal immune system phenotype J:198719
increased adenoma incidence J:198719
increased lymphoma incidence J:198719
increased sarcoma incidence J:198719
increased tumor incidence J:198719
premature death J:198719
normal reproductive system phenotype J:198719
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory