Spo11 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spo11
SPO11 initiator of meiotic double stranded breaks
MGI:1349669

38 phenotypes from 8 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc involves: C57BL/6	abnormal double-strand DNA break repair	J:202231
	abnormal uterus development	J:202231
	absent mature ovarian follicles	J:202231
	small ovary	J:202231
Spo11^tm1.1Gvpc/Spo11^tm3Rdco involves: C57BL/6	abnormal double-strand DNA break repair	J:202231
	abnormal X-Y chromosome synapsis during male meiosis	J:202231
	arrest of male meiosis	J:202231
	azoospermia	J:202231
	decreased mature ovarian follicle number	J:202231
	early reproductive senescence	J:202231
	male infertility	J:202231
	small ovary	J:202231
	small testis	J:202231
Spo11^tm1Bdm/Spo11^tm1Bdm involves: 129	abnormal double-strand DNA break repair	J:199075
	abnormal meiosis	J:199075
	abnormal oogenesis	J:199075
	abnormal synaptonemal complex	J:199075
	abnormal X-Y chromosome synapsis during male meiosis	J:199075
	arrest of spermatogenesis	J:199075
	female infertility	J:199075
	male infertility	J:199075
Spo11^tm1Mjn/Spo11⁺ B6.Cg-Spo11^tm1Mjn	abnormal double-strand DNA break repair	J:280261
Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ	abnormal female meiosis	J:192634
	abnormal meiosis	J:183982
	abnormal synaptonemal complex	J:236226
	decreased oocyte number	J:183982, J:192634
	decreased ovary weight	J:192634
	small ovary	J:192634
Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6	abnormal female meiosis	J:65880
	abnormal male meiosis	J:65880
	abnormal oogenesis	J:65880
	abnormal ovary morphology	J:65880
	abnormal spermatid morphology	J:65880
	abnormal spermatogenesis	J:65880
	arrest of spermatogenesis	J:65880
	azoospermia	J:65880
	decreased oocyte number	J:65880
	decreased primordial ovarian follicle number	J:65880
	decreased testis weight	J:65880
	female infertility	J:65880
	normal immune system phenotype	J:74754
	impaired ovarian folliculogenesis	J:65880
	male infertility	J:65880
	small ovary	J:65880
	small seminiferous tubules	J:65880
Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6J	abnormal chromosomal synapsis	J:209347
	abnormal double-strand DNA break repair	J:209347
	abnormal male meiosis	J:187173, J:209347
	arrest of male meiosis	J:209347
Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6JOlaHsd	abnormal female meiosis	J:173089
	arrest of spermatogenesis	J:173089
	decreased oocyte number	J:173089
	increased female germ cell apoptosis	J:173089
Spo11^tm1Nki/Spo11^tm1Nki involves: 129P2/OlaHsd	abnormal female meiosis	J:177475
	abnormal male meiosis	J:177475
	abnormal meiosis	J:177475
	abnormal synaptonemal complex	J:177475
	female infertility	J:177475
	male infertility	J:177475
Spo11^tm1Rdco/Spo11^tm1Rdco involves: 129 * C57BL/6	arrest of male meiosis	J:140402
Spo11^tm1Rdco/Spo11^tm1Rdco involves: 129S6/SvEvTac	abnormal female meiosis	J:65881
	abnormal female reproductive system morphology	J:65881
	abnormal fertility/fecundity	J:65881
	abnormal gametogenesis	J:65881
	abnormal male meiosis	J:194067
	abnormal male reproductive system morphology	J:65881
	abnormal ovary morphology	J:65881
	abnormal reproductive system morphology	J:65881
	abnormal seminiferous tubule morphology	J:65881
	abnormal spermatogenesis	J:65881
	arrest of male meiosis	J:65881
	female infertility	J:65881
	male infertility	J:65881
	small testis	J:65881
Spo11^tm2.1Rdco/Spo11^tm2.1Rdco B6.129S6-Spo11^tm2.1Rdco	abnormal male meiosis	J:194067
Spo11^tm2.1Rdco/Spo11^tm2.1Rdco B6.129S6-Spo11^tm2.1Rdco	arrest of male meiosis	J:194067
Spo11^{tm2b(KOMP)Wtsi}/Spo11^{tm2b(KOMP)Wtsi} C57BL/6N-Spo11^{tm2b(KOMP)Wtsi}/Bay	abnormal spleen morphology	J:211773
	increased spleen weight	J:211773
Spo11^tm3Rdco/Spo11^tm3Rdco involves: C57BL/6	abnormal reproductive system morphology	J:202231

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24