Spo11 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spo11
SPO11 initiator of meiotic double stranded breaks
MGI:1349669

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fignl1^tm1Osb/Fignl1^tm1.1Osb Spo11^tm1Mjn/Spo11^tm1Mjn Tg(Stra8-cre)1Osb/0 involves: 129X1/SvJ * C57BL/6	arrest of male meiosis	J:342157
Hormad1^tm1.2Atot/Hormad1^tm1.2Atot Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129/Sv * BALB/c * C57BL/6 * SJL	abnormal female meiosis	J:173089
	abnormal male meiosis	J:173089, J:292036
	abnormal synaptonemal complex	J:173089
	normal reproductive system phenotype	J:173089
Hormad1^tm1Atot/Hormad1^tm1Atot Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd	abnormal female meiosis	J:173089
	abnormal male meiosis	J:173089
	abnormal synaptonemal complex	J:173089
	normal reproductive system phenotype	J:173089
Hormad1^tm1Kura/Hormad1^tm1Kura Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	abnormal female meiosis	J:213984
	abnormal male germ cell apoptosis	J:213984
	abnormal male meiosis	J:213984
	normal reproductive system phenotype	J:213984
Hormad2^tm1.2Atot/Hormad2^tm1.2Atot Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL	abnormal meiosis	J:183982
	normal reproductive system phenotype	J:183982
Hormad2^tm1Atot/Hormad2^tm1Atot Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd	abnormal meiosis	J:183982
	normal reproductive system phenotype	J:183982
Hormad2^tm1Kura/Hormad2⁺ Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal female meiosis	J:192634
	decreased oocyte number	J:192634
	normal reproductive system phenotype	J:192634
Hormad2^tm1Kura/Hormad2^tm1Kura Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal female meiosis	J:192634
	abnormal testis morphology	J:192634
	normal reproductive system phenotype	J:192634
Mael^tm1Bort/Mael^tm1Bort Spo11^tm1Rdco/Spo11^tm1Rdco involves: 129 * C57BL/6	abnormal male meiosis	J:140402
Mcmdc2^{tm3b(EUCOMM)Hmgu}/Mcmdc2^{tm3b(EUCOMM)Hmgu} Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6N * CD-1	abnormal double-strand DNA break repair	J:236226
	abnormal synaptonemal complex	J:236226
Meioc^{tm1a(KOMP)Wtsi}/Meioc^{tm1a(KOMP)Wtsi} Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6N	absent oocytes	J:231231
	arrest of male meiosis	J:231231
	azoospermia	J:231231
Psmc3ip^tm1Rdco/Psmc3ip^tm1Rdco Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc involves: 129S6/SvEvTac * C57BL/6	abnormal double-strand DNA break repair	J:202231
Rad21l^tm1Yow/Rad21l^tm1Yow Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal chromosomal synapsis	J:209347
	abnormal male meiosis	J:209347
	abnormal synaptonemal complex	J:209347
Rad50^tm4.1Jpt/Rad50⁺ Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129/Sv * C57BL/6	abnormal seminiferous tubule morphology	J:209141
Rec8^mei8/Rec8^mei8 Spo11^tm1Mjn/Spo11^tm1Mjn involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J	abnormal male meiosis	J:209347
	abnormal synaptonemal complex	J:209347
Spo11^tm1Mjn/Spo11⁺ Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi} B6.Cg-Spo11^tm1Mjn Stag3^{tm1e.1(KOMP)Wtsi}/2J	abnormal double-strand DNA break repair	J:280261
Spo11^tm1Mjn/Spo11^tm1Mjn Syce2^{Gt(FHCRC-GT-S8-7E1)Sor}/Syce2^{Gt(FHCRC-GT-S8-7E1)Sor} involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6JOlaHsd	arrest of spermatogenesis	J:173089

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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