About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf5
interferon regulatory factor 5
MGI:1350924
14 phenotypes from 4 alleles in 5 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Irf5em1(IMPC)Bay/Irf5em1(IMPC)Bay
C57BL/6N-Irf5em1(IMPC)Bay/BayMmucd 		preweaning lethality, complete penetrance J:211773
Irf5tm1e(EUCOMM)Wtsi/Irf5tm1e(EUCOMM)Wtsi
C57BL/6N-Irf5tm1e(EUCOMM)Wtsi/Wtsi 		decreased CD4-positive, alpha-beta memory T cell number J:211773
decreased leukocyte cell number J:211773
Irf5tm1Ppr/Irf5tm1Ppr
involves: C57BL/6 		no abnormal phenotype detected J:176418
Irf5tm1Ttg/Irf5tm1Ttg
B6.129P2-Irf5tm1Ttg 		abnormal response to infection J:182658
decreased interferon-alpha secretion J:182658
decreased interleukin-6 secretion J:182658
decreased tumor necrosis factor secretion J:182658
normal immune system phenotype J:182658
Irf5tm1Ttg/Irf5tm1Ttg
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 physiology J:97567
decreased circulating interleukin-6 level J:97567
decreased circulating interleukin-12b level J:97567
decreased circulating tumor necrosis factor level J:97567
decreased susceptibility to bacterial infection J:97567
normal immune system phenotype J:182658
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory