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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irf5
interferon regulatory factor 5
MGI:1350924
14 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irf5em1(IMPC)Bay/Irf5em1(IMPC)Bay
C57BL/6N-Irf5em1(IMPC)Bay/BayMmucd 		preweaning lethality, complete penetrance J:211773
Irf5tm1e(EUCOMM)Wtsi/Irf5tm1e(EUCOMM)Wtsi
C57BL/6N-Irf5tm1e(EUCOMM)Wtsi/Wtsi 		decreased CD4-positive, alpha-beta memory T cell number J:211773
decreased leukocyte cell number J:211773
Irf5tm1Ppr/Irf5tm1Ppr
involves: C57BL/6 		no abnormal phenotype detected J:176418
Irf5tm1Ttg/Irf5tm1Ttg
B6.129P2-Irf5tm1Ttg 		abnormal response to infection J:182658
decreased interferon-alpha secretion J:182658
decreased interleukin-6 secretion J:182658
decreased tumor necrosis factor secretion J:182658
normal immune system phenotype J:182658
Irf5tm1Ttg/Irf5tm1Ttg
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 physiology J:97567
decreased circulating interleukin-6 level J:97567
decreased circulating interleukin-12b level J:97567
decreased circulating tumor necrosis factor level J:97567
decreased susceptibility to bacterial infection J:97567
normal immune system phenotype J:182658
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory