About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trp53bp1
transformation related protein 53 binding protein 1
MGI:1351320
35 phenotypes from 6 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
involves: 129S5/SvEvBrd 		abnormal T cell differentiation J:83164
chromosomal instability J:83164
decreased body weight J:83164
decreased cell proliferation J:83164
decreased litter size J:83164
decreased mature B cell number J:83164
decreased T cell number J:83164
increased mortality induced by gamma-irradiation J:83164
induced chromosome breakage J:83164
postnatal growth retardation J:83164
small thymus J:83164
spontaneous chromosome breakage J:83164
thymus hypoplasia J:83164
Trp53bp1m2Btlr/Trp53bp1m2Btlr
C57BL/6J-Trp53bp1m2Btlr 		decreased B cell number J:254841
decreased CD8-positive, naive alpha-beta T cell number J:254841
decreased IgD level J:254841
decreased IgG level J:254841
impaired humoral immune response J:254841
increased central memory CD4-positive, alpha-beta T cell number J:254841
Trp53bp1m3Btlr/Trp53bp1m3Btlr
C57BL/6J-Trp53bp1m3Btlr 		decreased IgD level J:254848
Trp53bp1m4Btlr/Trp53bp1m4Btlr
C57BL/6J-Trp53bp1m4Btlr 		decreased IgD level J:254852
Trp53bp1m5Btlr/Trp53bp1m5Btlr
C57BL/6J-Trp53bp1m5Btlr 		decreased IgD level J:272848
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129 		abnormal cell physiology J:194603
abnormal class switch recombination J:194603, J:231089, J:307190
abnormal DNA repair J:195061
abnormal double-strand DNA break repair J:231089
increased cellular sensitivity to hydroxyurea J:194603
increased cellular sensitivity to ionizing radiation J:194603, J:231089
Trp53bp1tm1Jc/Trp53bp1tm1Jc
involves: 129 * C57BL/6 		abnormal cell cycle checkpoint function J:82512
aneuploidy J:82512
chromosomal instability J:82512
decreased body size J:82512
decreased body weight J:82512
decreased CD4-positive, alpha-beta T cell number J:82512
decreased cell proliferation J:82512
decreased litter size J:82512
increased cellular sensitivity to ionizing radiation J:82512
increased double-negative T cell number J:82512
increased lymphoma incidence J:82512
increased mortality induced by ionizing radiation J:82512
increased T cell derived lymphoma incidence J:82512
postnatal growth retardation J:82512
premature death J:82512
normal reproductive system phenotype J:82512
thymus hypoplasia J:82512
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory