Trp53bp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trp53bp1
transformation related protein 53 binding protein 1
MGI:1351320

35 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Trp53bp1^{Gt(OST94324)Lex}/Trp53bp1^{Gt(OST94324)Lex} involves: 129S5/SvEvBrd	abnormal T cell differentiation	J:83164
	chromosomal instability	J:83164
	decreased body weight	J:83164
	decreased cell proliferation	J:83164
	decreased litter size	J:83164
	decreased mature B cell number	J:83164
	decreased T cell number	J:83164
	increased mortality induced by gamma-irradiation	J:83164
	induced chromosome breakage	J:83164
	postnatal growth retardation	J:83164
	small thymus	J:83164
	spontaneous chromosome breakage	J:83164
	thymus hypoplasia	J:83164
Trp53bp1^m2Btlr/Trp53bp1^m2Btlr C57BL/6J-Trp53bp1^m2Btlr	decreased B cell number	J:254841
	decreased CD8-positive, naive alpha-beta T cell number	J:254841
	decreased IgD level	J:254841
	decreased IgG level	J:254841
	impaired humoral immune response	J:254841
	increased central memory CD4-positive, alpha-beta T cell number	J:254841
Trp53bp1^m3Btlr/Trp53bp1^m3Btlr C57BL/6J-Trp53bp1^m3Btlr	decreased IgD level	J:254848
Trp53bp1^m4Btlr/Trp53bp1^m4Btlr C57BL/6J-Trp53bp1^m4Btlr	decreased IgD level	J:254852
Trp53bp1^m5Btlr/Trp53bp1^m5Btlr C57BL/6J-Trp53bp1^m5Btlr	decreased IgD level	J:272848
Trp53bp1^tm1Jc/Trp53bp1^tm1Jc involves: 129	abnormal cell physiology	J:194603
	abnormal class switch recombination	J:194603, J:231089, J:307190
	abnormal DNA repair	J:195061
	abnormal double-strand DNA break repair	J:231089
	increased cellular sensitivity to hydroxyurea	J:194603
	increased cellular sensitivity to ionizing radiation	J:194603, J:231089
Trp53bp1^tm1Jc/Trp53bp1^tm1Jc involves: 129 * C57BL/6	abnormal cell cycle checkpoint function	J:82512
	aneuploidy	J:82512
	chromosomal instability	J:82512
	decreased body size	J:82512
	decreased body weight	J:82512
	decreased CD4-positive, alpha-beta T cell number	J:82512
	decreased cell proliferation	J:82512
	decreased litter size	J:82512
	increased cellular sensitivity to ionizing radiation	J:82512
	increased double-negative T cell number	J:82512
	increased lymphoma incidence	J:82512
	increased mortality induced by ionizing radiation	J:82512
	increased T cell derived lymphoma incidence	J:82512
	postnatal growth retardation	J:82512
	premature death	J:82512
	normal reproductive system phenotype	J:82512
	thymus hypoplasia	J:82512

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24