Grm1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grm1
glutamate receptor, metabotropic 1
MGI:1351338

61 phenotypes from 14 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grm1^crv4/Grm1⁺ BALB/cPas-Grm1^crv4	abnormal podocyte morphology	J:169685
	albuminuria	J:169685
	increased renal glomerulus basement membrane thickness	J:169685
	podocyte foot process effacement	J:169685
Grm1^crv4/Grm1^crv4 BALB/cPas-Grm1^crv4	abnormal glomerular filtration barrier function	J:169685
	abnormal podocyte morphology	J:169685
	abnormal proximal convoluted tubule morphology	J:169685
	abnormal renal glomerulus basement membrane morphology	J:169685
	albuminuria	J:169685
	ataxia	J:112290
	decreased body size	J:112290
	glomerulosclerosis	J:169685
	increased brown adipose tissue amount	J:112290
	increased renal glomerulus basement membrane thickness	J:169685
	increased susceptibility to injury	J:169685
	kyphoscoliosis	J:112290
	male infertility	J:112290
	muscle spasm	J:112290
	narrow eye opening	J:112290
	normal nervous system phenotype	J:112290
	podocyte foot process effacement	J:169685
	reduced female fertility	J:112290
	renal cast	J:169685
	tremors	J:112290
Grm1^m1Btlr/Grm1^m1Btlr C57BL/6J-Grm1^m1Btlr	ataxia	J:224657
	kyphosis	J:224657
	premature death	J:224657
Grm1^nmf373/Grm1^nmf373 C57BL/6J-Grm1^nmf373/J	ataxia	J:87349
	limb grasping	J:87349
	tremors	J:87349
Grm1^rcw-2J/Grm1^rcw-2J either: B6(129X1)-Grm1^rcw-2J/J or B6.129X1 Bax^tm1Sjk/J-Grm1^rcw-2J/J	abnormal maternal nurturing	J:97119
	abnormal sexual interaction	J:97119
	ataxia	J:97119
	decreased body size	J:97119
Grm1^rcw-3J/Grm1^rcw-3J C57BL/6J-Grm1^rcw-3J/GrsrJ	ataxia	J:98757
	decreased body size	J:98757
	normal nervous system phenotype	J:98757
Grm1^rcw-4J/Grm1^rcw-4J C57BL/6J-Grm1^rcw-4J/GrsrJ	abnormal maternal nurturing	J:104879
	abnormal nervous system electrophysiology	J:104879
	abnormal sexual interaction	J:104879
	ataxia	J:104879
	decreased body size	J:104879
Grm1^rcw/Grm1^rcw 129S1;C3Fe-Grm1^rcw	abnormal gait	J:83427
	impaired balance	J:83427
	limb grasping	J:83427
Grm1^tm1Crpl/Grm1^tm1Crpl involves: 129P2/OlaHsd * C57BL/6	abnormal spatial learning	J:21644
	ataxia	J:21644
	decreased exploration in new environment	J:21644
	impaired righting response	J:21644
	reduced long-term depression	J:21644
	reduced long-term potentiation	J:21644
	tremors	J:21644
Grm1^tm1Crpl/Grm1^tm1Crpl Not Specified	reduced long-term potentiation	J:97042
Grm1^tm1Dgen/Grm1^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	ataxia	J:101679
	decreased body size	J:101679
	decreased body weight	J:101679
	decreased bone mineral content	J:101679
	decreased bone mineral density	J:101679
	decreased locomotor activity	J:101679
	hunched posture	J:101679
	impaired limb coordination	J:101679
	premature death	J:101679
	weakness	J:101679
Grm1^tm1Kyo/Grm1^tm1Kyo involves: C57BL/6	abnormal nervous system electrophysiology	J:101301
Grm1^tm1Kyo/Grm1^tm1Kyo involves: C57BL/6	normal behavior/neurological phenotype	J:101301
Grm1^tm1Stl/Grm1^tm1Stl involves: 129S2/SvPas * C57BL/6	abnormal contextual conditioning behavior	J:21086
	abnormal excitatory postsynaptic currents	J:73385
	ataxia	J:21086
	normal nervous system phenotype	J:21086
	reduced fertility	J:21086
	reduced long-term potentiation	J:21086
	short excitatory postsynaptic current decay time	J:73385
	tremors	J:21086
Grm1^tvrm84/Grm1^tvrm84 C57BL/6J-Grm1^tvrm84/Pjn	abnormal electroretinogram waveform feature	J:241495
Grm1^tvrm84/Grm1^tvrm84 C57BL/6J-Grm1^tvrm84/Pjn	ataxia	J:241495
Grm1^wobl/Grm1^wobl C57BL/6Apb-Grm1^wobl/Apb	abnormal fertility/fecundity	J:104190
Grm1^wobl/Grm1^wobl C57BL/6Apb-Grm1^wobl/Apb	ataxia	J:104190
Tg(Dct-Grm1)ESzc/0 C57BL/6J-Tg(Dct-Grm1)ESzc	abnormal ciliary body morphology	J:230115
	abnormal melanocyte proliferation	J:230115
	abnormal optic choroid morphology	J:230115
	anterior iris synechia	J:230115
	increased intraocular melanoma incidence	J:230115
	increased melanocyte number	J:230115
	retina degeneration	J:230115
	retina detachment	J:230115
Tg(Dct-Grm1)ESzc/0 involves: C57BL/6J	abnormal melanocyte proliferation	J:83183
	enlarged inguinal lymph nodes	J:83183
	enlarged submandibular lymph nodes	J:83183
	hyperpigmentation	J:83183
	increased cutaneous melanoma incidence	J:83183
	increased ear pigmentation	J:83183
	increased tail pigmentation	J:83183

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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