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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grm7
glutamate receptor, metabotropic 7
MGI:1351344
87 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Smn1tm1Msd/Smn1tm1Msd
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N 		lethality, complete penetrance J:256720
Mnx1tm4(cre)Tmj/Mnx1+
Smn1tm1Cdid/Smn1tm1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * 129S1/Sv * C57BL/6 * FVB 		abnormal innervation J:183080
abnormal motor coordination/balance J:183080
abnormal righting response J:183080
normal behavior/neurological phenotype J:183080
decreased body weight J:183080
decreased heart rate J:183080
decreased motor neuron number J:183080
irregular heartbeat J:183080
lethargy J:183080
normal nervous system phenotype J:183080
postnatal lethality, complete penetrance J:183080
prolonged PR interval J:183080
prolonged QT interval J:183080
Olig2tm1(cre)Tmj/Olig2+
Smn1tm1Jme/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:164292
Olig2tm1(cre)Tmj/Olig2+
Smn1tm1Jme/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129 * 129P2/OlaHsd * FVB/N 		abnormal CNS synaptic transmission J:164292
abnormal miniature endplate potential J:164292
abnormal muscle morphology J:164292
abnormal neuromuscular synapse morphology J:164292
abnormal PNS synaptic transmission J:164292
abnormal sensory neuron innervation pattern J:164292
abnormal synaptic bouton morphology J:164292
abnormal synaptic transmission J:164292
decreased body weight J:164292
decreased grip strength J:164292
decreased skeletal muscle fiber number J:164292
decreased survivor rate J:164292
increased skeletal muscle fiber size J:164292
kyphosis J:164292
motor neuron degeneration J:164292
muscle weakness J:164292
muscular atrophy J:164292
premature death J:164292
skeletal muscle fiber degeneration J:164292
Smn1tm1Cdid/Smn1tm1.1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * C57BL/6 * FVB 		no abnormal phenotype detected J:183080
Smn1tm1Cdid/Smn1tm1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * C57BL/6 * FVB 		abnormal innervation pattern to muscle J:183080
abnormal motor capabilities/coordination/movement J:183080
abnormal neuromuscular synapse morphology J:183080
abnormal spinal cord morphology J:183080
decreased body weight J:183080
decreased heart rate J:183080
decreased motor neuron number J:183080
decreased single cell response threshold J:183080
impaired righting response J:183080
motor neuron degeneration J:183080
paralysis J:183080
postnatal lethality, complete penetrance J:183080
prolonged PR interval J:183080
prolonged QRS complex duration J:183080
prolonged QT interval J:183080
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd 		postnatal lethality, complete penetrance J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/?
involves: 129P2/OlaHsd * C57BL/6J * FVB 		abnormal suckling behavior J:60592
bradykinesia J:60592
motor neuron degeneration J:60592
normal muscle phenotype J:60592
perinatal lethality, incomplete penetrance J:60592
postnatal lethality, complete penetrance J:60592
respiratory distress J:60592
tremors J:60592
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*delta7)4299Ahmb/0
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb 		postnatal lethality, complete penetrance J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*A111G)588Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		normal mortality/aging J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*A111G)591Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		normal mortality/aging J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd 		decreased body weight J:97103
lethality, complete penetrance J:256720
postnatal lethality, complete penetrance J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J 		abnormal innervation pattern to muscle J:132467
abnormal neuromuscular synapse morphology J:132467
decreased body weight J:194969
decreased skeletal muscle fiber diameter J:132467
normal mortality/aging J:256720
postnatal lethality J:194969
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		prenatal lethality, incomplete penetrance J:164444
thin interventricular septum J:164444
thin ventricular wall J:164444
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*)1951Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*A111G)588Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		abnormal gastrocnemius morphology J:148541
abnormal skeletal muscle morphology J:148541
normal mortality/aging J:148541
normal nervous system phenotype J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*A111G)591Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		normal mortality/aging J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/0
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J 		cardiac interstitial fibrosis J:194969
decreased body weight J:194969
decreased skeletal muscle fiber size J:194969
postnatal lethality J:194969
thin interventricular septum J:194969
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb 		abnormal gait J:97103
abnormal neuromuscular synapse morphology J:97103
decreased body weight J:97103
decreased motor neuron number J:97103
impaired balance J:97103
impaired limb coordination J:97103
impaired righting response J:97103
postnatal lethality, complete penetrance J:97103
skeletal muscle fiber atrophy J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J 		abnormal blood flow velocity J:164446
abnormal heart morphology J:164446
abnormal innervation pattern to muscle J:132467
abnormal neuromuscular synapse morphology J:132467
abnormal sympathetic system morphology J:164446
decreased body size J:164446
decreased heart rate J:164446
decreased skeletal muscle fiber diameter J:132467
dilated cardiomyopathy J:164446
increased heart rate variability J:164446
postnatal lethality, complete penetrance J:164446
prolonged PR interval J:164446
prolonged QRS complex duration J:164446
weight loss J:164446
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
involves: 129P2/OlaHsd * FVB/N 		abnormal artery morphology J:164444
abnormal interventricular septum morphology J:164444
cardiac interstitial fibrosis J:164444
decreased heart rate J:164444
increased heart left ventricle size J:164444
oxidative stress J:164444
prolonged RR interval J:164444
thin interventricular septum J:164444
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		decreased skeletal muscle fiber size J:131663
premature death J:131663
tail necrosis J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(Prnp-SMN)92Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		premature death J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(Prnp-SMN)92Ahmb/Tg(Prnp-SMN)92Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		decreased skeletal muscle fiber size J:131663
normal nervous system phenotype J:131663
premature death J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129P2/OlaHsd * FVB/N 		abnormal action potential J:81238
abnormal axon morphology J:81238
abnormal motor nerve collateral sprouting J:81238
abnormal motor neuron morphology J:81238
abnormal muscle electrophysiology J:81238
abnormal neuromuscular synapse morphology J:81238
decreased body size J:81238
decreased locomotor activity J:81238
decreased motor neuron number J:81238
hypopnea J:81238
limb grasping J:81238
motor neuron degeneration J:81238
muscular atrophy J:81238
neuronal intranuclear inclusions J:81238
poor grooming J:81238
premature death J:81238
reduced fertility J:81238
weight loss J:81238
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		abnormal lumbar dorsal root ganglion morphology J:131663
decreased motor neuron number J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/Tg(SMN1*A2G)2023Ahmb
Grm7Tg(SMN2)89Ahmb/?
involves: 129P2/OlaHsd * FVB/N 		abnormal motor nerve collateral sprouting J:81238
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1-SMN2*)16Cll/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal neuromuscular synapse morphology J:194969
normal behavior/neurological phenotype J:194969
cardiac interstitial fibrosis J:194969
decreased body size J:194969
decreased grip strength J:194969
decreased skeletal muscle fiber size J:194969
epidermal necrosis J:194969
impaired coordination J:194969
impaired righting response J:194969
premature death J:194969
thin interventricular septum J:194969
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory