Casr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Casr
calcium-sensing receptor
MGI:1351351

63 phenotypes from 10 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Casr^BCH002/Casr^BCH002 C3HeB/FeJ-Casr^BCH002	abnormal coat/hair pigmentation	J:183993
	decreased body size	J:183993
	decreased circulating phosphate level	J:183993
	increased circulating calcium level	J:183993
Casr^BCH003/Casr^BCH003 C3HeB/FeJ-Casr^BCH003	increased circulating calcium level	J:183993
Casr^BCH004/Casr^BCH004 C3HeB/FeJ-Casr^BCH004	increased circulating calcium level	J:183993
Casr^BCH007/Casr^BCH007 C3HeB/FeJ-Casr^BCH007	decreased body size	J:183993
Casr^BCH007/Casr^BCH007 C3HeB/FeJ-Casr^BCH007	increased circulating calcium level	J:183993
Casr^BCH011/Casr^BCH011 C3HeB/FeJ-Casr^BCH011	increased circulating calcium level	J:183993
Casr^BCH013/Casr^BCH013 C3HeB/FeJ-Casr^BCH013	increased circulating calcium level	J:183993
Casr^Nuf/Casr⁺ either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)	cataract	J:92612
	decreased circulating calcium level	J:92612
	decreased circulating parathyroid hormone level	J:92612
	increased circulating phosphate level	J:92612
Casr^Nuf/Casr^Nuf involves: 102/El * C3H/He	calcified muscle	J:92612
	calcinosis	J:92612
	cataract	J:92612
	decreased circulating calcium level	J:92612
	decreased circulating parathyroid hormone level	J:92612
	decreased urine calcium level	J:92612
	decreased urine phosphate level	J:92612
	increased circulating phosphate level	J:92612
	nephrocalcinosis	J:92612
	premature death	J:92612
	tongue inflammation	J:92612
Casr^{tm1b(KOMP)Mbp}/Casr⁺ C57BL/6N-Casr^{tm1b(KOMP)Mbp}/Tcp	abnormal pancreas morphology	J:211773
	edema	J:211773
	enlarged uterus	J:211773
	increased circulating calcium level	J:211773
	increased circulating phosphate level	J:211773
	small superior vagus ganglion	J:211773
Casr^{tm1b(KOMP)Mbp}/Casr^{tm1b(KOMP)Mbp} C57BL/6N-Casr^{tm1b(KOMP)Mbp}/Tcp	preweaning lethality, complete penetrance	J:211773
Casr^tm1Ces/Casr⁺ involves: 129X1/SvJ * Black Swiss	decreased urine calcium level	J:29900
	normal endocrine/exocrine gland phenotype	J:29900
	normal growth/size/body region phenotype	J:29900
	normal hematopoietic system phenotype	J:29900
	increased circulating calcium level	J:29900
	increased circulating magnesium level	J:29900
	increased circulating parathyroid hormone level	J:29900
	normal renal/urinary system phenotype	J:29900
	normal skeleton phenotype	J:29900
Casr^tm1Ces/Casr^tm1Ces involves: 129X1/SvJ * Black Swiss	abnormal bone mineralization	J:71056
	abnormal parathyroid gland chief cell morphology	J:29900
	abnormal postural reflex	J:29900
	abnormal posture	J:29900
	aphagia	J:29900
	decreased body size	J:71056
	decreased body weight	J:71056
	decreased bone mineral density	J:29900
	decreased circulating phosphate level	J:71056
	decreased urine calcium level	J:29900
	dehydration	J:29900
	delayed bone ossification	J:71056
	enlarged parathyroid gland	J:29900
	increased circulating calcium level	J:29900
	increased circulating magnesium level	J:29900
	increased circulating parathyroid hormone level	J:29900
	increased hematocrit	J:29900
	increased width of hypertrophic chondrocyte zone	J:71056
	kyphoscoliosis	J:29900
	lethargy	J:29900
	parathyroid gland hyperplasia	J:29900
	pigmented parathyroid gland	J:29900
	postnatal growth retardation	J:29900
	postnatal lethality, complete penetrance	J:29900, J:71056
	rickets	J:71056
Casr^tm1Wch/Casr⁺ Tg(PTH-cre)4167Slib/0 involves: 129S4/SvJae * C57BL/6 * FVB	decreased bone mineral density	J:180651
	decreased bone trabecula number	J:180651
	decreased compact bone thickness	J:180651
	decreased compact bone volume	J:180651
	decreased trabecular bone thickness	J:180651
	increased circulating calcium level	J:180651
	increased circulating parathyroid hormone level	J:180651
	increased urine calcium level	J:180651
	normal skeleton phenotype	J:180651
Casr^tm1Wch/Casr^tm1Wch Tg(Col1a1-cre)2Bek/0 involves: 129S4/SvJae * C57BL/6 * CD-1	abnormal skeleton development	J:180651
	abnormal skeleton morphology	J:180651
	abnormal trabecular bone morphology	J:180651
	decreased body size	J:180651
	decreased body weight	J:180651
	decreased bone mineral density	J:180651
	decreased bone mineralization	J:180651
	decreased bone trabecula number	J:180651
	decreased compact bone thickness	J:180651
	decreased compact bone volume	J:180651
	decreased trabecular bone connectivity density	J:180651
	decreased trabecular bone thickness	J:180651
	decreased trabecular bone volume	J:180651
	fragile skeleton	J:180651
	postnatal growth retardation	J:180651
	postnatal lethality, complete penetrance	J:180651
Casr^tm1Wch/Casr^tm1Wch Tg(Col2a1-cre)1Bhr/0 involves: 129S4/SvJae * C57BL/6 * SJL	abnormal skeleton development	J:180651
	decreased bone mineralization	J:180651
	embryonic lethality during organogenesis, incomplete penetrance	J:180651
	lethality throughout fetal growth and development, complete penetrance	J:180651
Casr^tm1Wch/Casr^tm1Wch Tg(Col2a1-cre/ERT)KA3Smac/0 involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal skeleton development	J:180651
	decreased bone mineralization	J:180651
	increased width of hypertrophic chondrocyte zone	J:180651
Casr^tm1Wch/Casr^tm1Wch Tg(PTH-cre)4167Slib/0 involves: 129S4/SvJae * C57BL/6 * FVB	abnormal skeleton development	J:180651
	abnormal skeleton morphology	J:180651
	decreased body weight	J:180651
	decreased bone mineral content	J:180651
	decreased bone mineral density	J:180651
	decreased bone mineralization	J:180651
	fragile skeleton	J:180651
	increased circulating calcium level	J:180651
	increased circulating parathyroid hormone level	J:180651
	increased urine calcium level	J:180651
	postnatal growth retardation	J:180651
	postnatal lethality, complete penetrance	J:180651
Casr^tm1Wch/Casr^tm1Wch Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: 129S4/SvJae * C57BL/6 * CD-1	abnormal skeleton development	J:180651
	abnormal trabecular bone morphology	J:180651
	decreased body size	J:180651
	decreased bone mineralization	J:180651
	decreased bone trabecula number	J:180651
	decreased compact bone volume	J:180651
	decreased trabecular bone connectivity density	J:180651
	decreased trabecular bone thickness	J:180651
	decreased trabecular bone volume	J:180651
	postnatal growth retardation	J:180651
	normal skeleton phenotype	J:180651
Casr^tm1Wch/Casr^tm1Wch Tg(Vil1-cre)997Gum/0 involves: 129S4/SvJae * C57BL/6J * SJL	abnormal enterocyte proliferation	J:179672
	abnormal large intestine crypts of Lieberkuhn morphology	J:179672

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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