Pdk4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
MGI:1351481

20 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdk4^tm1Rhar/Pdk4^tm1Rhar B6.129-Pdk4^tm1Rhar	abnormal blood homeostasis	J:115895
	abnormal circulating amino acid level	J:115895
	abnormal glucose homeostasis	J:115895
	abnormal glycerol level	J:115895
	decreased circulating alanine level	J:115895
	decreased circulating glucose level	J:115895
	decreased circulating lactate level	J:115895
	decreased liver glycogen level	J:115895
	improved glucose tolerance	J:115895
	increased circulating free fatty acids level	J:115895
	increased circulating insulin level	J:115895
	increased circulating ketone body level	J:115895
	ketosis	J:115895
Pdk4^tm1Tok/Pdk4^tm1Tok B6.129P2-Pdk4^tm1Tok	abnormal bone volume	J:179789
	abnormal osteoclast cell number	J:179789
	abnormal osteoclast differentiation	J:179789
	abnormal osteoclast morphology	J:179789
	abnormal trabecular bone morphology	J:179789
	abnormal trabecular bone thickness	J:179789
	abnormal trabecular bone volume	J:179789

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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