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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Npas3
neuronal PAS domain protein 3
MGI:1351610
43 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Npas3tm1b(KOMP)Wtsi/Npas3+
C57BL/6N-Npas3tm1b(KOMP)Wtsi/Kmpc 		increased startle reflex J:211773
no spontaneous movement J:211773
unresponsive to tactile stimuli J:211773
Npas3tm1b(KOMP)Wtsi/Npas3tm1b(KOMP)Wtsi
C57BL/6N-Npas3tm1b(KOMP)Wtsi/Kmpc 		no spontaneous movement J:211773
preweaning lethality, complete penetrance J:211773
unresponsive to tactile stimuli J:211773
Npas3tm1Ewb/Npas3tm1Ewb
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal behavioral response to xenobiotic J:101561
abnormal cerebellar foliation J:101561
abnormal cingulate gyrus morphology J:101561
abnormal corpus callosum morphology J:101561
abnormal gait J:101561
abnormal hippocampus morphology J:101561
abnormal nest building behavior J:101561
abnormal reflex J:101561
abnormal response to novel object J:101561
abnormal response to novelty J:101561
abnormal retrosplenial region morphology J:101561
abnormal startle reflex J:101561
decreased anxiety-related response J:101561
decreased body weight J:101561
enlarged cerebral aqueduct J:101561
enlarged fourth ventricle J:101561
enlarged lateral ventricles J:101561
enlarged third ventricle J:101561
impaired coordination J:101561
increased exploration in new environment J:101561
limb grasping J:101561
short stride length J:101561
Npas3tm1Mesu/Npas3+
B6.129S6-Npas3tm1Mesu 		abnormal lung vasculature morphology J:150793
emphysema J:150793
impaired lung alveolus development J:150793
increased airway resistance J:150793
overexpanded pulmonary alveolus J:150793
Npas3tm1Mesu/Npas3tm1Mesu
B6.129S6-Npas3tm1Mesu 		abnormal pulmonary alveolar parenchyma morphology J:150793
bronchiectasis J:150793
cyanosis J:150793
dilated respiratory conducting tube J:150793
impaired branching involved in trachea morphogenesis J:150793
overexpanded pulmonary alveolus J:150793
postnatal lethality, incomplete penetrance J:150793
respiratory distress J:150793
Npas3tm1Slm/Npas3tm1Slm
involves: 129S/SvEv * C57BL/6 		abnormal maternal nurturing J:92610
abnormal social investigation J:92610
decreased body size J:92610
hyperactivity J:92610
short stride length J:92610
stereotypic behavior J:92610
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory