Abca3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Abca3
ATP-binding cassette, sub-family A member 3
MGI:1351617

28 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Abca3^{tm1b(EUCOMM)Hmgu}/Abca3^{tm1b(EUCOMM)Hmgu} C57BL/6N-Abca3^{tm1b(EUCOMM)Hmgu}/Bay	preweaning lethality, complete penetrance	J:211773
Abca3^tm1Dgen/Abca3⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal lung development	J:124809
	abnormal surfactant physiology	J:124809
	decreased alveolar lamellar body number	J:124809
Abca3^tm1Dgen/Abca3^tm1Dgen involves: 129P2/OlaHsd * C57BL/6J	abnormal pulmonary alveolus morphology	J:124809
	abnormal surfactant secretion	J:124809
	absent alveolar lamellar bodies	J:124809
	neonatal lethality, complete penetrance	J:124809
	prenatal lethality, incomplete penetrance	J:124809
	thick pulmonary interalveolar septum	J:124809
Abca3^tm1Frm/Abca3^tm1Frm involves: 129S/SvEv	abnormal lipid homeostasis	J:120296
	abnormal surfactant secretion	J:120296
	absent alveolar lamellar bodies	J:120296
	cyanosis	J:120296
	lethargy	J:120296
	neonatal lethality, complete penetrance	J:120296
	primary atelectasis	J:120296
	pulmonary alveolar hemorrhage	J:120296
	normal renal/urinary system phenotype	J:120296
	respiratory failure	J:120296
Abca3^tm1Holz/Abca3^tm1Holz involves: 129S6/SvEvTac * C57BL/6	abnormal alveolar lamellar body morphology	J:122736
	abnormal surfactant physiology	J:122736
	abnormal type II pneumocyte morphology	J:122736
	atelectasis	J:122736
	cyanosis	J:122736
	lethargy	J:122736
	neonatal lethality, complete penetrance	J:122736
	respiratory distress	J:122736
	respiratory failure	J:122736
Abca3^tm1Nina/Abca3^tm1Nina involves: 129P2/OlaHsd * C57BL/6J	abnormal alveolar lamellar body morphology	J:121155
	abnormal bronchiole epithelium morphology	J:121155
	abnormal lung development	J:121155
	abnormal lung saccule morphology	J:121155
	abnormal surfactant composition	J:121155
	abnormal type II pneumocyte morphology	J:121155
	absent alveolar lamellar bodies	J:121155
	absent type I pneumocytes	J:121155
	atelectasis	J:121155
	cyanosis	J:121155
	increased wet-to-dry lung weight ratio	J:121155
	neonatal lethality, complete penetrance	J:121155
	pulmonary vascular congestion	J:121155
	respiratory failure	J:121155
	thick lung-associated mesenchyme	J:121155

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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