Prmt5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prmt5
protein arginine N-methyltransferase 5
MGI:1351645

34 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prmt5^{Gt(RRA014)Byg}/Prmt5^{Gt(RRA014)Byg} involves: 129P2/OlaHsd	absent inner cell mass proliferation	J:166736
	embryonic lethality, complete penetrance	J:166736
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL	decreased embryo size	J:201152
	embryonic growth retardation	J:201152
	pallor	J:201152
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(BGLAP-cre)1Clem/0 involves: C57BL/6N * FVB/NJ	normal skeleton phenotype	J:283043
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Col2a1-cre)#Amc/0 involves: C57BL/6N	abnormal chondrocyte morphology	J:283043
	abnormal endochondral bone ossification	J:283043
	abnormal intervertebral disk development	J:283043
	abnormal intervertebral disk morphology	J:283043
	abnormal vertebrae morphology	J:283043
	abnormal vertebral body development	J:283043
	decreased body size	J:283043
	decreased bone mineralization	J:283043
	decreased trabecular bone volume	J:283043
	delayed endochondral bone ossification	J:283043
	preweaning lethality, complete penetrance	J:283043
	scoliosis	J:283043
	small vertebrae	J:283043
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0 involves: C57BL/6N	abnormal intervertebral disk morphology	J:283043
	normal skeleton phenotype	J:283043
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0 B6.Cg-Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln	abnormal cerebellum external granule cell layer morphology	J:201152
	abnormal cortical plate morphology	J:201152
	abnormal embryonic/fetal subventricular zone morphology	J:201152
	abnormal lateral ventricle morphology	J:201152
	abnormal neuronal precursor proliferation	J:201152
	akinesia	J:201152
	decreased brain size	J:201152
	decreased brain weight	J:201152
	decreased cortical ventricular zone cell density	J:201152
	enlarged lateral ventricles	J:201152
	impaired balance	J:201152
	increased neuron apoptosis	J:201152
	postnatal lethality, complete penetrance	J:201152
	thin cerebral cortex	J:201152
	tremors	J:201152

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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