Nr2f1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr2f1
nuclear receptor subfamily 2, group F, member 1
MGI:1352451

49 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr2f1^{tm1.1(KOMP)Mbp}/Nr2f1⁺ C57BL/6N-Nr2f1^{tm1.1(KOMP)Mbp}/J	abnormal auditory brainstem response	J:211773
	persistence of hyaloid vascular system	J:211773
Nr2f1^{tm1.1(KOMP)Mbp}/Nr2f1^{tm1.1(KOMP)Mbp} C57BL/6N-Nr2f1^{tm1.1(KOMP)Mbp}/J	embryonic growth retardation	J:211773
	preweaning lethality, complete penetrance	J:211773
Nr2f1^tm1Mist/Nr2f1^tm1Mist involves: 129S2/SvPas * C57BL/6J	abnormal anterior commissure morphology	J:114098
	abnormal axon guidance	J:114098
	abnormal axon morphology	J:114098
	abnormal brain commissure morphology	J:114098
	abnormal cerebral cortex morphology	J:114098
	abnormal cingulate gyrus morphology	J:114098
	abnormal corpus callosum morphology	J:114098
	abnormal hippocampal commissure morphology	J:114098
	abnormal neuron morphology	J:114098
	perinatal lethality, complete penetrance	J:114098
Nr2f1^tm1Mjts/Nr2f1⁺ involves: 129S7/SvEvBrd	abnormal dorsal striatum morphology	J:286647
	abnormal long-term depression	J:286647
	normal behavior/neurological phenotype	J:286647
	decreased body weight	J:286647
	decreased grip strength	J:286647
	decreased hippocampus volume	J:286647
	decreased startle reflex	J:286647
	hypotonia	J:286647
	impaired hearing	J:286647
	impaired righting response	J:286647
	impaired synaptic plasticity	J:286647
	increased neocortex volume	J:286647
	increased or absent threshold for auditory brainstem response	J:286647
	reduced long-term potentiation	J:286647
	slow extinction of fear memory	J:286647
	normal vision/eye phenotype	J:286647
Nr2f1^tm1Mjts/Nr2f1^tm1Mjts involves: 129S7/SvEvBrd	abnormal cerebral cortex morphology	J:59182, J:71195
	abnormal cochlear hair cell development	J:112461
	abnormal cochlear sensory epithelium morphology	J:112461
	abnormal hearing physiology	J:59182
	abnormal organ of Corti supporting cell differentiation	J:112461
	abnormal orientation of inner hair cell stereociliary bundles	J:112461
	abnormal orientation of outer hair cell stereociliary bundles	J:112461
	absent barrels in primary somatosensory cortex	J:59182
	increased cochlear hair cell number	J:112461
	increased cochlear inner hair cell number	J:112461
	increased cochlear outer hair cell number	J:112461
	increased Deiters cell number	J:112461
	short scala media	J:112461
Nr2f1^tm1Mjts/Nr2f1^tm1Mjts involves: 129S7/SvEvBrd * C57BL/6	abnormal axon guidance	J:42259
	abnormal glossopharyngeal ganglion morphology	J:42259
	neonatal lethality, incomplete penetrance	J:42259
	normal nervous system phenotype	J:42259
	no swallowing reflex	J:42259
Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist involves: 129S2/SvPas * C57BL/6J	no abnormal phenotype detected	J:127387
Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist Emx1^tm1(cre)Krj/Emx1⁺ involves: 129S2/SvPas * C57BL/6J	abnormal barrel cortex morphology	J:127387
	abnormal cerebral cortex morphology	J:127387
	abnormal primary somatosensory cortex morphology	J:127387
	normal nervous system phenotype	J:127387
Nr2f1^tm2.1Mjts/Nr2f1^tm2.1Mjts Tg(rx3-icre)1Mjam/0 involves: 129	normal vision/eye phenotype	J:157924

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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