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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr4a2
nuclear receptor subfamily 4, group A, member 2
MGI:1352456
47 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
involves: 129S1/Sv * 129X1/SvJ 		abnormal regulatory T cell morphology J:205658
abnormal regulatory T cell physiology J:205658
Nr4a2tm1.1Pcn/Nr4a2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal regulatory T cell morphology J:205658
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Not Specified 		akinesia J:157098
decreased dopamine level J:157098
decreased dopaminergic neuron number J:157098
normal nervous system phenotype J:157098
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac 		abnormal regulatory T cell morphology J:205658
abnormal T-helper 1 cell differentiation J:205658
abnormal T-helper 17 cell differentiation J:205658
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Slc6a3tm1(cre)Lrsn/Slc6a3tm1(cre)Lrsn
involves: 129S1/Sv * 129X1/SvJ 		abnormal dopaminergic neuron morphology J:157098
abnormal response/metabolism to endogenous compounds J:157098
decreased body size J:157098
decreased dopamine level J:157098
decreased locomotor activity J:157098
decreased vertical activity J:157098
hyperactivity J:157098
increased serotonin level J:157098
increased stereotypic behavior J:157098
lethality at weaning, complete penetrance J:157098
neuron degeneration J:157098
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Tg(Lck-cre)1Jtak/0
Not Specified 		abnormal regulatory T cell morphology J:205658
abnormal T-helper 1 cell differentiation J:205658
abnormal T-helper 17 cell differentiation J:205658
decreased regulatory T cell number J:205658
normal immune system phenotype J:205658
increased CD4-positive, alpha-beta T cell number J:205658
increased susceptibility to induced colitis J:205658
increased susceptibility to weight loss J:205658
increased T-helper 1 cell number J:205658
neonatal lethality, incomplete penetrance J:205658
Nr4a2tm1Niko/Nr4a2tm1Niko
involves: 129S4/SvJae 		decreased dopamine level J:47684
dehydration J:47684
loss of dopaminergic neurons J:47684
neonatal lethality, complete penetrance J:47684
normal nervous system phenotype J:47684
Nr4a2tm1Omc/Nr4a2+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal locomotor activation J:104902
abnormal midbrain development J:106612
decreased dopamine level J:104902
impaired coordination J:104902
Nr4a2tm1Omc/Nr4a2tm1Omc
involves: 129S7/SvEvBrd * C57BL/6 		abnormal midbrain development J:46856
abnormal substantia nigra morphology J:46856
abnormal suckling behavior J:106612
abnormal tegmentum morphology J:46856
decreased dopamine level J:46856
decreased locomotor activity J:106612
decreased noradrenaline level J:106612
increased midbrain apoptosis J:46856
neonatal lethality, complete penetrance J:46856, J:106612
Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2tm1Tpe 		abnormal dopamine level J:147544
abnormal noradrenaline level J:147544
abnormal serotonin level J:147544
behavioral despair J:147544
enhanced behavioral response to addictive substance J:147544
enhanced behavioral response to xenobiotic J:147544
hyperactivity J:147544
impaired passive avoidance behavior J:147544
increased locomotor activity J:147544
Nr4a2tm1Tpe/Nr4a2+
involves: 129P2/OlaHsd 		decreased dopamine level J:39661
Nr4a2tm1Tpe/Nr4a2tm1Tpe
involves: 129P2/OlaHsd 		abnormal motor capabilities/coordination/movement J:39661
abnormal nervous system development J:39661
abnormal suckling behavior J:39661
decreased dopamine level J:39661
decreased locomotor activity J:39661
impaired righting response J:39661
loss of dopaminergic neurons J:39661
neonatal lethality, complete penetrance J:39661
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory