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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr0b1
nuclear receptor subfamily 0, group B, member 1
MGI:1352460
39 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nr0b1em2(IMPC)Wtsi/Y
C57BL/6N-Nr0b1em2(IMPC)Wtsi/Wtsi 		abnormal reproductive system morphology J:211773
increased bone mineral content J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating iron level J:211773
increased circulating LDL cholesterol level J:211773
increased circulating magnesium level J:211773
increased circulating serum albumin level J:211773
increased hemoglobin content J:211773
Nr0b1tm1.1Lja/Y
involves: 129S1/Sv * 129X1/SvJ 		abnormal efferent ductules of testis morphology J:71710
abnormal fetal Leydig cell differentiation J:81356
abnormal Leydig cell morphology J:71710
abnormal lipid homeostasis J:71710
abnormal peritubular myoid cell morphology J:71710
abnormal seminiferous tubule epithelium morphology J:51292, J:71710
abnormal Sertoli cell development J:81356
abnormal spermatogenesis J:51292
abnormal testis cord formation J:81356
abnormal testis morphology J:51292
absent germ cells J:51292
decreased male germ cell number J:51292
decreased number of peritubular myoid cells J:81356
decreased testis weight J:51292, J:71710
dilated seminiferous tubule J:71710
disorganized testis cords J:81356
ectopic Leydig cells J:71710, J:81356
ectopic Sertoli cells J:71710
normal endocrine/exocrine gland phenotype J:51292
increased Leydig cell number J:51292, J:71710
increased Sertoli cell proliferation J:71710
increased testis tumor incidence J:71710
male infertility J:51292, J:71710
rete testis obstruction J:71710
retention of the adrenal gland x-zone J:51292
seminiferous tubule degeneration J:51292, J:71710
small testis J:51292
Nr0b1tm1.1Lja/Nr0b1tm1.1Lja
involves: 129S1/Sv * 129X1/SvJ 		polyovular ovarian follicle J:51292
Nr0b1tm1Lja/Y
C57BL/6JEi 		abnormal primary sex determination J:98922
primary sex reversal J:98922
Nr0b1tm1Lja/Y
involves: C57BL/6JEi * DBA/2J 		abnormal primary sex determination J:98922
ovotestis J:98922
primary sex reversal J:98922
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory