Nr1h3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462

37 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr1h3^{tm1.1(KOMP)Vlcg}/Nr1h3^{tm1.1(KOMP)Vlcg} C57BL/6N-Nr1h3^{tm1.1(KOMP)Vlcg}/Ucd	abnormal kidney morphology	J:211773
	increased circulating alanine transaminase level	J:211773
Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S/SvEv * C57BL/6 * DBA	abnormal lipid homeostasis	J:184536
	decreased physiological sensitivity to xenobiotic	J:184536
	increased liver cholesterol level	J:184536
	increased liver weight	J:184536
Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cellular cholesterol metabolism	J:82096
	enlarged liver	J:82096
	increased circulating alanine transaminase level	J:82096
	increased circulating LDL cholesterol level	J:82096
	increased liver cholesterol level	J:82096
	pale liver	J:82096
	normal respiratory system phenotype	J:234268
Nr1h3^tm1.1Nph/Nr1h3^tm1.1Nph B6.129-Nr1h3^tm1.1Nph	normal homeostasis/metabolism phenotype	J:169945
Nr1h3^tm1Dgen/Nr1h3^tm1Dgen Not Specified	abnormal cholesterol homeostasis	J:112995
	abnormal hepatobiliary system physiology	J:112995
	abnormal lipid homeostasis	J:112995
Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	abnormal bile salt homeostasis	J:47971
	abnormal corpus luteum morphology	J:158168
	abnormal ovary physiology	J:158168
	abnormal superovulation	J:158168
	decreased circulating luteinizing hormone level	J:120913
	decreased circulating testosterone level	J:120913
	enlarged ovary	J:158168
	hepatic steatosis	J:47971
	normal homeostasis/metabolism phenotype	J:243753
	increased circulating alanine transaminase level	J:47971
	increased circulating aspartate transaminase level	J:47971
	increased circulating cholesterol level	J:47971
	increased circulating estradiol level	J:158168
	increased circulating LDL cholesterol level	J:47971
	increased erythrocyte sedimentation rate	J:158168
	increased inflammatory response	J:158168
	increased liver cholesterol level	J:47971, J:243753
	increased liver weight	J:47971
	increased male germ cell apoptosis	J:120913
	increased susceptibility to bacterial infection	J:81696
	increased susceptibility to induced morbidity/mortality	J:81696
	increased vascular permeability	J:158168
	liver degeneration	J:47971
	ovary cyst	J:158168
	ovary hemorrhage	J:158168
	pale liver	J:47971
Nr1h3^tm1Gstr/Nr1h3^tm1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:82096
Nr1h3^tm1Wexi/Nr1h3^tm1Wexi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased susceptibility to endotoxin shock	J:155709
	hepatic steatosis	J:155709
Tg(Fabp1-Nr1h3)#Wexi/? involves: 129X1/SvJ * C57BL/6	enlarged liver	J:135594
	hepatic steatosis	J:135594
	increased liver triglyceride level	J:135594

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24