Nr1h3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462

37 phenotypes from 9 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr1h3^{tm1.1(KOMP)Vlcg}/Nr1h3^{tm1.1(KOMP)Vlcg} C57BL/6N-Nr1h3^{tm1.1(KOMP)Vlcg}/Ucd	abnormal kidney morphology	J:211773
	increased circulating alanine transaminase level	J:211773
Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S/SvEv * C57BL/6 * DBA	abnormal lipid homeostasis	J:184536
	decreased physiological sensitivity to xenobiotic	J:184536
	increased liver cholesterol level	J:184536
	increased liver weight	J:184536
Nr1h3^tm1.1Gstr/Nr1h3^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cellular cholesterol metabolism	J:82096
	enlarged liver	J:82096
	increased circulating alanine transaminase level	J:82096
	increased circulating LDL cholesterol level	J:82096
	increased liver cholesterol level	J:82096
	pale liver	J:82096
	normal respiratory system phenotype	J:234268
Nr1h3^tm1.1Nph/Nr1h3^tm1.1Nph B6.129-Nr1h3^tm1.1Nph	normal homeostasis/metabolism phenotype	J:169945
Nr1h3^tm1Dgen/Nr1h3^tm1Dgen Not Specified	abnormal cholesterol homeostasis	J:112995
	abnormal hepatobiliary system physiology	J:112995
	abnormal lipid homeostasis	J:112995
Nr1h3^tm1Djm/Nr1h3^tm1Djm involves: 129S6/SvEvTac * C57BL/6	abnormal bile salt homeostasis	J:47971
	abnormal corpus luteum morphology	J:158168
	abnormal ovary physiology	J:158168
	abnormal superovulation	J:158168
	decreased circulating luteinizing hormone level	J:120913
	decreased circulating testosterone level	J:120913
	enlarged ovary	J:158168
	hepatic steatosis	J:47971
	normal homeostasis/metabolism phenotype	J:243753
	increased circulating alanine transaminase level	J:47971
	increased circulating aspartate transaminase level	J:47971
	increased circulating cholesterol level	J:47971
	increased circulating estradiol level	J:158168
	increased circulating LDL cholesterol level	J:47971
	increased erythrocyte sedimentation rate	J:158168
	increased inflammatory response	J:158168
	increased liver cholesterol level	J:47971, J:243753
	increased liver weight	J:47971
	increased male germ cell apoptosis	J:120913
	increased susceptibility to bacterial infection	J:81696
	increased susceptibility to induced morbidity/mortality	J:81696
	increased vascular permeability	J:158168
	liver degeneration	J:47971
	ovary cyst	J:158168
	ovary hemorrhage	J:158168
	pale liver	J:47971
Nr1h3^tm1Gstr/Nr1h3^tm1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:82096
Nr1h3^tm1Wexi/Nr1h3^tm1Wexi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased susceptibility to endotoxin shock	J:155709
	hepatic steatosis	J:155709
Tg(Fabp1-Nr1h3)#Wexi/? involves: 129X1/SvJ * C57BL/6	enlarged liver	J:135594
	hepatic steatosis	J:135594
	increased liver triglyceride level	J:135594

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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