Nr1h2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr1h2
nuclear receptor subfamily 1, group H, member 2
MGI:1352463

32 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr1h2^tm1.1Gstr/Nr1h2⁺ involves: 129 * C57BL/6	normal reproductive system phenotype	J:101966
Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr involves: 129 * C57BL/6	abnormal Sertoli cell morphology	J:101966
Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cellular cholesterol metabolism	J:82096
	abnormal lipid level	J:234268
	abnormal lung morphology	J:234268
	abnormal oligodendrocyte morphology	J:278794
	abnormal optic nerve morphology	J:278794
	abnormal retina ganglion cell morphology	J:278794
	abnormal retina morphology	J:278794
	abnormal retina nerve fiber layer morphology	J:278794
	amyloid beta deposits	J:278794
	decreased oligodendrocyte number	J:278794
	decreased retina ganglion cell number	J:278794
	increased microglial cell activation	J:278794
	optic nerve degeneration	J:278794
Nr1h2^tm1.1Nph/Nr1h2^tm1.1Nph B6.129-Nr1h2^tm1.1Nph	abnormal cellular cholesterol metabolism	J:169945
	abnormal cholesterol homeostasis	J:169945
	abnormal glucose homeostasis	J:169945
	abnormal glycogen homeostasis	J:169945
	abnormal lipid homeostasis	J:169945
	increased muscle cell glucose uptake	J:169945
Nr1h2^tm1Dgen/Nr1h2^tm1Dgen B6.129-Nr1h2^tm1Dgen	abnormal skeleton physiology	J:157551
Nr1h2^tm1Djm/Nr1h2^tm1Djm involves: 129S6/SvEvTac	thin epidermis	J:89874
Nr1h2^tm1Djm/Nr1h2^tm1Djm involves: 129S6/SvEvTac * C57BL/6	abnormal myometrium morphology	J:120923
	abnormal parturition	J:120923
	abnormal Sertoli cell morphology	J:120913
	abnormal spermatogonia proliferation	J:120913
	abnormal uterus physiology	J:120923
	hindlimb paralysis	J:120923
	impaired smooth muscle contractility	J:120923
	increased susceptibility to bacterial infection	J:81696
	increased susceptibility to induced morbidity/mortality	J:81696
	pregnancy-related premature death	J:120923
Nr1h2^tm1Gstr/Nr1h2^tm1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:82096

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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