Nr1h4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr1h4
nuclear receptor subfamily 1, group H, member 4
MGI:1352464

56 phenotypes from 5 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz Tg(Alb1-cre)1Dlr/0 involves: 129X1/SvJ * C57BL/6	increased bile salt level	J:129978
	increased circulating cholesterol level	J:129978
	increased circulating triglyceride level	J:129978
Nr1h4^tm1.1Gonz/Nr1h4^tm1.1Gonz Tg(Vil1-cre)997Gum/0 involves: 129X1/SvJ * C57BL/6 * SJL	abnormal bile salt homeostasis	J:129978
	increased bile salt level	J:129978
Nr1h4^tm1.1Mbj/Nr1h4^tm1.1Mbj B6N.B6-Nr1h4^tm1.1Mbj	abnormal liver perisinusoidal space morphology	J:200842
	abnormal liver physiology	J:200842
	abnormal liver sinusoid morphology	J:200842
	decreased body weight	J:200842
	decreased bone mineral content	J:200842
	decreased bone mineral density	J:200842
	decreased circulating free fatty acids level	J:200842
	decreased circulating glucose level	J:200842
	decreased circulating insulin level	J:200842
	decreased epididymal fat pad weight	J:200842
	decreased interscapular fat pad weight	J:200842
	decreased retroperitoneal fat pad weight	J:200842
	decreased total body fat amount	J:200842
	decreased white fat cell size	J:200842
	enlarged gallbladder	J:200842
	normal growth/size/body region phenotype	J:200842
	hepatic steatosis	J:200842
	normal homeostasis/metabolism phenotype	J:200842
	impaired glucose tolerance	J:200842
	increased bile salt level	J:200842
	increased cecum weight	J:200842
	increased circulating alanine transaminase level	J:200842
	increased circulating bilirubin level	J:200842
	increased circulating cholesterol level	J:200842
	increased energy expenditure	J:200842
	increased fluid intake	J:200842
	increased food intake	J:200842
	increased liver triglyceride level	J:200842
	increased liver weight	J:200842
	increased spleen weight	J:200842
	normal integument phenotype	J:200842
	jaundice	J:200842
	liver degeneration	J:200842
	liver inflammation	J:200842
Nr1h4^tm1.2Auw/Nr1h4^tm1.2Auw involves: 129 * C57BL/6J	abnormal hepatocyte morphology	J:157882
	increased bile salt level	J:157882
	increased hepatocyte apoptosis	J:157882
	increased hepatocyte proliferation	J:157882
Nr1h4^tm1Gonz/Nr1h4^tm1Gonz involves: 129	normal homeostasis/metabolism phenotype	J:118368
Nr1h4^tm1Gonz/Nr1h4^tm1Gonz involves: 129X1/SvJ	abnormal bile composition	J:129978
	increased bile salt level	J:129978
	increased circulating cholesterol level	J:129978
	increased circulating triglyceride level	J:129978
Nr1h4^tm1Gonz/Nr1h4^tm1Gonz involves: 129X1/SvJ * C57BL/6	abnormal liver morphology	J:118204
	enlarged liver	J:118204
	focal hepatic necrosis	J:118204
	increased bile salt level	J:118204
	increased circulating aspartate transaminase level	J:118204
	increased hepatocellular carcinoma incidence	J:118204
	increased hepatocyte apoptosis	J:118204
	increased liver adenoma incidence	J:118204
	increased liver tumor incidence	J:118204
	liver inflammation	J:118204
Nr1h4^tm1Gonz/Nr1h4^tm1Gonz involves: 129X1/SvJ * C57BL/6N	abnormal bile salt homeostasis	J:64792
	abnormal bile salt level	J:64792
	abnormal liver morphology	J:64792
	cachexia	J:64792
	decreased body temperature	J:64792
	decreased body weight	J:121075
	decreased susceptibility to weight gain	J:64792
	enlarged liver	J:121075
	hepatic steatosis	J:64792
	increased bile salt level	J:121075
	increased circulating cholesterol level	J:64792
	increased circulating phospholipid level	J:64792
	increased circulating triglyceride level	J:64792
	increased hepatocellular carcinoma incidence	J:121075
	increased hepatocyte apoptosis	J:121075
	increased hepatocyte proliferation	J:121075
	increased liver adenoma incidence	J:121075
	increased liver cholesterol level	J:64792
	increased liver triglyceride level	J:64792
	increased liver tumor incidence	J:121075
	increased susceptibility to induced morbidity/mortality	J:64792
Nr1h4^tm1Gonz/Nr1h4^tm1Gonz STOCK Nr1h4^tm1Gonz/J	increased circulating alanine transaminase level	J:149005
	increased circulating aspartate transaminase level	J:149005
	increased circulating cholesterol level	J:149005
	increased circulating triglyceride level	J:149005
Nr1h4^tm1Kok/Nr1h4^tm1Kok involves: 129P2/OlaHsd * C57BL/6J	abnormal bile composition	J:86154
	abnormal bile salt homeostasis	J:86154
	abnormal bile secretion	J:86154
	abnormal blood homeostasis	J:86154
	increased bile salt level	J:86154

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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