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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr2c2
nuclear receptor subfamily 2, group C, member 2
MGI:1352466
77 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nr2c2tm1Amj/Nr2c2tm1Amj
B6.129-Nr2c2tm1Amj 		abnormal blood homeostasis J:169333
abnormal eating behavior J:169333
abnormal energy homeostasis J:169333
abnormal gas homeostasis J:169333
abnormal glucose homeostasis J:169333
abnormal lipid homeostasis J:169333
abnormal white adipose tissue physiology J:169333
decreased abdominal fat pad weight J:169333
decreased body fat mass J:169333
decreased body weight J:169333
decreased brown adipose tissue mass J:169333
decreased circulating alanine transaminase level J:169333
decreased circulating aspartate transaminase level J:169333
decreased circulating cholesterol level J:169333
decreased circulating glucose level J:169333
decreased circulating insulin level J:169333
decreased circulating LDL cholesterol level J:169333
decreased circulating triglyceride level J:169333
decreased epididymal fat pad weight J:169333
decreased inflammatory response J:169333
decreased liver triglyceride level J:169333
decreased susceptibility to age-related hepatic steatosis J:169333
decreased susceptibility to diet-induced hepatic steatosis J:169333
decreased susceptibility to diet-induced obesity J:169333
decreased white fat cell size J:169333
embryonic lethality during organogenesis, incomplete penetrance J:169333
increased carbon dioxide production J:169333
increased energy expenditure J:169333
increased oxygen consumption J:169333
increased respiratory quotient J:169333
Nr2c2tm1b(EUCOMM)Wtsi/Nr2c2+
C57BL/6N-Nr2c2tm1b(EUCOMM)Wtsi/Bay 		impaired glucose tolerance J:211773
Nr2c2tm1b(EUCOMM)Wtsi/Nr2c2tm1b(EUCOMM)Wtsi
C57BL/6N-Nr2c2tm1b(EUCOMM)Wtsi/Bay 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, incomplete penetrance J:211773
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Pax3tm1(cre)Joe/Pax3+
Not Specified 		abnormal mechanical nociception J:197895
decreased neuron number J:197895
decreased pruritus J:197895
increased chemical nociceptive threshold J:197895
increased thermal nociceptive threshold J:197895
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Camk2a-cre)#Stl/0
involves: BALB/c * C57BL 		normal integument phenotype J:197895
normal nervous system phenotype J:197895
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal mechanical nociception J:197895
abnormal neuron physiology J:197895
abnormal sympathetic afferent fiber morphology J:197895
abnormal touch/ nociception J:197895
normal behavior/neurological phenotype J:197895
decreased anxiety-related response J:197895
decreased body size J:197895
decreased neuron number J:197895
decreased pruritus J:197895
impaired coordination J:197895
increased chemical nociceptive threshold J:197895
increased thermal nociceptive threshold J:197895
Nr2c2tm1Bbm/Nr2c2tm1Bbm
Tg(Nr5a1-cre)#Lowl/0
involves: FVB 		normal integument phenotype J:197895
normal nervous system phenotype J:197895
Nr2c2tm1Chc/Nr2c2tm1Chc
Not Specified 		abnormal corpus luteum morphology J:133000
abnormal estrous cycle J:133000
abnormal hemoglobin J:121628
abnormal internal female genitalia morphology J:133000
abnormal ovary physiology J:133000
abnormal ovulation J:133000
arrest of male meiosis J:91602
decreased body size J:91602
decreased circulating estradiol level J:133000
decreased circulating progesterone level J:133000
decreased corpora lutea number J:133000
decreased litter size J:133000
decreased mature ovarian follicle number J:133000
decreased superovulation rate J:133000
decreased testis weight J:91602
delayed vaginal opening J:133000
impaired ovarian folliculogenesis J:133000
increased atretic ovarian follicle number J:133000
increased granulosa cell apoptosis J:133000
multinucleated giant male germ cells J:121628
oligozoospermia J:91602
prolonged diestrus J:133000
prolonged estrous cycle J:133000
reduced female fertility J:133000
reduced male fertility J:91602
seminiferous tubule degeneration J:91602
short estrus J:133000
short proestrus J:133000
small ovary J:133000
small uterus J:133000
small vagina J:133000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory