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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Esr1
estrogen receptor 1 (alpha)
MGI:1352467
259 phenotypes from 24 alleles in 32 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ctsktm1(cre)Ska/Ctsk+
Esr1tm1Mma/Esr1tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal osteoclast physiology J:127179
decreased bone mineral density of femur J:127179
increased bone mineralization J:127179
increased bone ossification J:127179
increased bone resorption J:127179
increased osteoclast cell number J:127179
osteoporosis J:127179
Esr1tm1.1(cre)And/Esr1+
B6.129S6(Cg)-Esr1tm1.1(cre)And 		abnormal social investigation J:207677
decreased aggression towards mice J:207677
increased aggression towards mice J:207677
Esr1tm1.1Gust/Esr1tm1.1Gust
B6.129X1-Esr1tm1.1Gust 		abnormal mammary gland development J:186230
absent corpus luteum J:186230
absent mature ovarian follicles J:186230
female infertility J:186230
increased body weight J:186230
increased circulating glucose level J:186230
male infertility J:186230
obese J:186230
ovary cyst J:186230
ovary hemorrhage J:186230
uterus hypoplasia J:186230
Esr1tm1.1Ics/Esr1tm1.1Ics
involves: C57BL/6NTac 		abnormal cell migration J:206373
abnormal ovary morphology J:206373
abnormal tertiary ovarian follicle morphology J:206373
abnormal vascular endothelial cell physiology J:206373
abnormal vasodilation J:206373
absent corpus luteum J:206373
decreased circulating progesterone level J:206373
decreased primordial ovarian follicle number J:206373
female infertility J:206373
increased circulating follicle stimulating hormone level J:206373
increased circulating luteinizing hormone level J:206373
ovarian follicular cyst J:206373
ovary hemorrhage J:206373
normal reproductive system phenotype J:206373
Esr1tm1.1Lja/Esr1+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal branching of the mammary ductal tree J:79228
abnormal ovary morphology J:79228
abnormal tertiary ovarian follicle morphology J:79228
abnormal uterus physiology J:79228
absent corpus luteum J:79228
decreased circulating progesterone level J:79228
decreased ovulation rate J:79228
endometrium hyperplasia J:79228
enlarged endometrial glands J:79228
enlarged uterus J:79228
female infertility J:79228
increased uterus weight J:79228
uterus cyst J:79228
Esr1tm1.1Lja/Esr1+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		abnormal bone structure J:128135
decreased areal bone mineral density J:128135
decreased bone mass J:128135
decreased compact bone area J:128135
decreased compact bone thickness J:128135
decreased volumetric bone mineral density J:128135
increased uterus weight J:128135
increased volumetric bone mineral density J:128135
short femur J:128135
Esr1tm1.1Lja/Esr1tm1.1Mma
involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal bone mineralization J:128135
abnormal bone structure J:128135
abnormal osteoclast physiology J:128135
abnormal volumetric bone mineral density J:128135
decreased bone mass J:128135
decreased circulating insulin-like growth factor I level J:128135
decreased compact bone area J:128135
decreased compact bone thickness J:128135
decreased uterus weight J:128135
decreased volumetric bone mineral density J:128135
increased circulating estradiol level J:128135
short femur J:128135
Esr1tm1.1Mma/Esr1tm1.1Mma
involves: 129S2/SvPas 		abnormal vasodilation J:206373
Esr1tm1.1Mma/Esr1tm1.1Mma
involves: 129S2/SvPas * C57BL/6 		abnormal bone marrow cell physiology J:171276
abnormal bone mineralization J:128135
abnormal immunoglobulin level J:171276
abnormal response/metabolism to endogenous compounds J:171276
abnormal skeleton physiology J:171276
abnormal thymus physiology J:171276
normal behavior/neurological phenotype J:72240
decreased uterus weight J:128135
decreased vertical activity J:72240
decreased volumetric bone mineral density J:128135
increased circulating estradiol level J:171276
increased circulating luteinizing hormone level J:171276
increased circulating testosterone level J:171276
increased volumetric bone mineral density J:128135
obese J:72240
normal reproductive system phenotype J:105626
Esr1tm1.1Mma/Esr1tm1.1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal ovarian folliculogenesis J:64426
abnormal ovary morphology J:64426
abnormal response/metabolism to endogenous compounds J:64426
abnormal rete testis morphology J:64426
abnormal seminiferous tubule morphology J:64426
absent corpus luteum J:64426
absent estrous cycle J:64426
decreased male germ cell number J:64426
female infertility J:64426
increased atretic ovarian follicle number J:64426
ovarian follicular cyst J:64426
uterus hypoplasia J:64426
vagina hypoplasia J:64426
Esr1tm1.1Ohl/Esr1tm1.1Ohl
involves: 129S2/SvPas 		normal cardiovascular system phenotype J:206373
Esr1tm1.1Ohl/Esr1tm1.1Ohl
involves: 129S2/SvPas * C57BL/6 		abnormal bone marrow cell physiology J:171276
abnormal immunoglobulin level J:171276
abnormal response/metabolism to endogenous compounds J:171276
abnormal skeleton physiology J:171276
abnormal thymus physiology J:171276
increased circulating estradiol level J:171276
increased circulating luteinizing hormone level J:171276
increased circulating testosterone level J:171276
Esr1tm1.1Pws/Esr1tm1.1Pws
involves: C57BL/6 * CBA 		abnormal reproductive system morphology J:163783
abnormal vascular wound healing J:163783
Esr1tm1.1Scma/Esr1tm1.1Scma
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal osteoclast physiology J:156947
abnormal skeleton development J:156947
abnormal trabecular bone morphology J:156947
decreased compact bone mass J:156947
increased osteoclast cell number J:156947
Esr1tm1.2Awo/Esr1tm1.2Awo
Kiss1tm1.1(cre)Uboe/Kiss1+
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal estrous cycle J:167285
absent corpus luteum J:167285
decreased circulating luteinizing hormone level J:167285
early vaginal opening J:167285
normal homeostasis/metabolism phenotype J:167285
increased circulating luteinizing hormone level J:167285
ovarian follicular cyst J:167285
ovary cyst J:167285
prolonged diestrus J:167285
normal reproductive system phenotype J:167285
Esr1tm1.2Awo/Esr1tm1.2Awo
Tg(Cga-cre)1Awo/0
involves: C57BL/6 * SJL 		abnormal estrous cycle J:152925
abnormal luteinizing hormone level J:152925
abnormal ovarian follicle morphology J:152925
absent corpus luteum J:152925
decreased circulating luteinizing hormone level J:152925
decreased corpora lutea number J:152925
decreased gonadotroph cell number J:152925
decreased litter size J:152925
female infertility J:152925
increased circulating estradiol level J:152925
increased circulating luteinizing hormone level J:152925
reduced female fertility J:152925
normal reproductive system phenotype J:152925
Esr1tm1.2Mma/Esr1tm1.2Mma
Tg(Cga-cre)3Sac/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL 		abnormal estrous cycle J:131949
female infertility J:131949
ovarian follicular cyst J:131949
Esr1tm1.2Mma/Esr1tm1.2Mma
Tg(Cyp17a1-icre)AJako/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal estrous cycle J:151908
abnormal ovarian follicle number J:151908
abnormal ovary morphology J:151908
abnormal theca cell layer morphology J:151908
decreased circulating luteinizing hormone level J:151908
decreased corpora lutea number J:151908
decreased superovulation rate J:151908
early reproductive senescence J:151908
female infertility J:151908
increased circulating testosterone level J:151908
increased gonadotroph cell number J:151908
increased theca cell number J:151908
oocyte degeneration J:151908
ovary cyst J:151908
ovary hemorrhage J:151908
prolonged diestrus J:151908
Esr1tm1.2Mma/Esr1tm1.2Mma
Tg(Wnt7a-EGFP/cre)#Bhr/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal uterine receptivity J:167551
abnormal uterus morphology J:167551
abnormal uterus size J:167551
Esr1tm1Arnal/Esr1tm1Arnal
involves: C57BL/6 		abnormal immunoglobulin level J:171276
abnormal response/metabolism to endogenous compounds J:144952, J:171276
abnormal skeleton physiology J:171276
increased circulating estradiol level J:171276
increased circulating luteinizing hormone level J:171276
increased circulating testosterone level J:171276
increased osteoclast cell number J:171276
infertility J:144952
Esr1tm1Geog/Esr1tm1Geog
involves: 129X1/SvJ * C57BL/6 		abnormal mammary gland development J:135981
abnormal response/metabolism to endogenous compounds J:135981
abnormal uterus morphology J:135981
abnormal vagina morphology J:135981
absent corpus luteum J:135981
anovulation J:135981
decreased physiological sensitivity to xenobiotic J:135981
female infertility J:135981
impaired granulosa cell differentiation J:135981
increased body size J:135981
increased body weight J:135981
increased circulating estradiol level J:135981
increased circulating luteinizing hormone level J:135981
increased circulating testosterone level J:135981
increased gonadal fat pad weight J:135981
increased mammary fat pad weight J:135981
increased tertiary ovarian follicle number J:135981
increased theca cell number J:135981
ovarian follicular cyst J:135981
small uterus J:135981
uterus hypoplasia J:135981
vagina hypoplasia J:135981
Esr1tm1Gsc/Esr1tm1Gsc
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal endometrium morphology J:117231
abnormal luteinizing hormone level J:117231
abnormal ovary morphology J:117231
abnormal theca cell layer morphology J:117231
absent corpus luteum J:117231
absent endometrial glands J:117231
dilated uterus J:117231
endometrium atrophy J:117231
female infertility J:117231
increased tertiary ovarian follicle number J:117231
normal nervous system phenotype J:117231
Esr1tm1Ksk/Esr1+
involves: 129P2/OlaHsd 		abnormal cremaster muscle morphology J:112350
abnormal testis morphology J:112350
Esr1tm1Ksk/Esr1tm1Ksk
B6.129P2-Esr1tm1Ksk 		abnormal nociception after inflammation J:151022
normal adipose tissue phenotype J:65806
normal behavior/neurological phenotype J:65806
decreased birth weight J:65806
decreased energy expenditure J:65806
hyporesponsive to tactile stimuli J:151022
impaired glucose tolerance J:65806
impaired passive avoidance behavior J:65785
increased body weight J:65806
increased epididymal fat pad weight J:65806
increased inguinal fat pad weight J:65806
increased parametrial fat pad weight J:65806
increased renal fat pad weight J:65806
increased white adipose tissue amount J:65806
increased white fat cell number J:65806
increased white fat cell size J:65806
insulin resistance J:65806
Esr1tm1Ksk/Esr1tm1Ksk
B6.129P2-Esr1tm1Ksk/J 		oligozoospermia J:147000
seminiferous tubule degeneration J:147000
Esr1tm1Ksk/Esr1tm1Ksk
involves: 129P2/OlaHsd 		abnormal bone marrow cell number J:110923
abnormal chondrocyte physiology J:111108
abnormal cremaster muscle morphology J:112350
abnormal efferent ductules of testis morphology J:60490
abnormal epididymis epithelium morphology J:60490, J:83231
abnormal epididymis morphology J:60490
abnormal internal male genitalia morphology J:112350
abnormal long bone epiphyseal plate morphology J:111108
abnormal male reproductive system physiology J:83231
abnormal mammary gland development J:64639
abnormal ovary morphology J:64639
abnormal physiological response to xenobiotic J:135833
abnormal pituitary gland physiology J:40607
abnormal response/metabolism to endogenous compounds J:131313, J:152738
abnormal skeleton development J:111108
abnormal testis morphology J:60490, J:112350
abnormal testis weight J:83231
abnormal vagina epithelium morphology J:72221
abnormal vertebrae morphology J:111108
absent corpus luteum J:55147, J:64639
albuminuria J:152738
anovulation J:64639
normal cardiovascular system phenotype J:163783
decreased body length J:111108
decreased circulating estradiol level J:152738
decreased circulating prolactin level J:64639
decreased circulating testosterone level J:152738
decreased immature B cell number J:110923
decreased lactotroph cell number J:40607
decreased long bone epiphyseal plate size J:111108
decreased mature B cell number J:110923
decreased physiological sensitivity to xenobiotic J:72221
decreased uterus weight J:72221, J:152738
dilated efferent ductule of testis J:60490, J:83231, J:125658
dilated rete testis J:83231, J:125658
expanded mesangial matrix J:152738
failure of embryo implantation J:108638
failure of superovulation J:55147
normal hematopoietic system phenotype J:110923
impaired glucose tolerance J:151012
impaired ovarian folliculogenesis J:55147
increased body weight J:72221, J:152738
increased circulating estradiol level J:72221
increased circulating glucose level J:151012
increased circulating testosterone level J:152738
insulin resistance J:151012
male infertility J:125658
oligozoospermia J:60490
ovarian follicular cyst J:55147, J:64639, J:72221
ovary hemorrhage J:55147, J:64639
renal glomerulus hypertrophy J:152738
seminiferous tubule degeneration J:112350
short femur J:111108
spermatic granuloma J:60490
uterus hypoplasia J:72221
Esr1tm1Ksk/Esr1tm1Ksk
involves: 129P2/OlaHsd * 129S6/SvEvTac 		dilated seminiferous tubule J:84989
increased circulating estradiol level J:84989
Esr1tm1Ksk/Esr1tm1Ksk
involves: 129P2/OlaHsd * C57BL/6 		abnormal response of heart to induced stress J:62353
Esr1tm1Ksk/Esr1tm1Ksk
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal mammary gland development J:54215
Esr1tm1Ksk/Esr1tm1Ksk
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell number J:82423
abnormal bone marrow cell number J:82423
abnormal class switch recombination J:82423
abnormal endometrium morphology J:85911
abnormal epididymis morphology J:36658
abnormal female reproductive system physiology J:16338
abnormal hypothalamus morphology J:99716
abnormal immunoglobulin level J:82423
abnormal innervation J:85911
abnormal intromission J:38600
abnormal kidney physiology J:88156
abnormal lymph node cell ratio J:88156
abnormal maternal nurturing J:51468
abnormal mating receptivity J:16338, J:51468
abnormal mesonephros morphology J:108807
abnormal ovary morphology J:16338
abnormal pup retrieval J:51468
abnormal response/metabolism to endogenous compounds J:82423
abnormal seminiferous tubule epithelium morphology J:36658
abnormal seminiferous tubule morphology J:36658
abnormal spermatogenesis J:36658
abnormal spleen physiology J:88156
abnormal uterus morphology J:85911
absent corpus luteum J:16338
asthenozoospermia J:36658
cortical renal glomerulopathies J:88156
decreased aggression J:38600
decreased aggression towards male mice J:66582
decreased areal bone mineral density J:62222
decreased body weight J:62222
decreased bone mineral content J:62222
decreased bone mineral density of femur J:62222
decreased bone mineralization J:91765
decreased bone ossification J:91765
decreased bone strength J:62222
decreased CD4-positive, alpha-beta T cell number J:110416
decreased CD8-positive, alpha-beta T cell number J:110416
decreased circulating insulin-like growth factor I level J:62222, J:114164
decreased circulating osteocalcin level J:62222
decreased compact bone area J:62222
decreased copulatory plug deposition J:36658
decreased femoral compact bone area J:62222
decreased heart weight J:62222
decreased length of long bones J:114164
decreased lung weight J:62222
decreased osteoblast cell number J:91765
decreased testis weight J:16338, J:36658
decreased uterus weight J:114164
detached sperm flagellum J:36658
dilated rete testis J:36658
dilated seminiferous tubule J:36658
failure of ejaculation J:38600, J:66582
female infertility J:16338
glomerulonephritis J:88156
hyperactivity J:38600
impaired fertilization J:36658
increased aggression towards female mice J:51468
increased anti-double stranded DNA antibody level J:88156
increased body weight J:114164
increased circulating cholesterol level J:66077
increased circulating estradiol level J:112080
increased circulating HDL cholesterol level J:66077
increased circulating leptin level J:66077
increased circulating testosterone level J:36658
increased compact bone area J:91765
increased double-positive T cell number J:110416
increased gonadal fat pad weight J:66077
increased IgG3 level J:88156
increased plasma cell number J:88156
increased retroperitoneal fat pad weight J:66077
increased spleen germinal center number J:88156
increased total body fat amount J:66077
increased urine protein level J:88156
increased vertical activity J:38600
insulin resistance J:66077
male infertility J:36658
obese J:66077
oligozoospermia J:16338, J:36658
ovarian follicular cyst J:16338
pup cannibalization J:51468
reduced male fertility J:16338
reduced male mating frequency J:51468
renal glomerular immunoglobulin deposits J:88156
seminiferous tubule degeneration J:36658
short femur J:62222, J:114164
short tibia J:114164
short ulna J:91765
normal skeleton phenotype J:114164
small uterus J:85911
teratozoospermia J:36658
thymus hypoplasia J:110416
uterus hypoplasia J:16338
Esr1tm1Ksk/Esr1tm1Ksk
involves: 129P2/OlaHsd * C57BL/6N 		abnormal B cell differentiation J:63462
abnormal definitive hematopoiesis J:63462
abnormal thymus physiology J:111590
decreased B cell number J:63462
decreased immature B cell number J:63462
decreased mature B cell number J:63462
decreased thymocyte number J:111590
decreased thymus weight J:111590
Esr1tm1Sakh/Esr1tm1Sakh
Tg(MMTV-cre)4Mam/?
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal branching of the mammary ductal tree J:124962
Esr1tm1Sakh/Esr1tm1Sakh
Tg(Wap-cre)11738Mam/?
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal branching of the mammary ductal tree J:124962
abnormal lactation J:124962
abnormal mammary gland alveolus morphology J:124962
abnormal mammary gland morphology J:124962
Esr1tm1Syeh/Esr1tm1Syeh
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129X1/SvJ * FVB/N 		abnormal female reproductive system morphology J:147191
abnormal granulosa cell morphology J:147191
abnormal male reproductive system morphology J:147191
abnormal myometrium morphology J:147191
abnormal ovary morphology J:147191
abnormal prostate gland branching morphogenesis J:147000
abnormal prostate gland physiology J:147000
abnormal reproductive system physiology J:147191
absent corpus luteum J:147191
decreased male germ cell number J:147000
decreased primary ovarian follicle number J:147191
decreased primordial ovarian follicle number J:147191
decreased testis weight J:147000
female infertility J:147191
impaired ovarian folliculogenesis J:147191
increased atretic ovarian follicle number J:147191
increased circulating testosterone level J:147000
increased total body fat amount J:147191
male infertility J:147000
obese J:147191
oligozoospermia J:147000
ovary cyst J:147191
seminiferous tubule degeneration J:147000
small testis J:147000
uterus hypoplasia J:147191
vagina hypoplasia J:147191
Esr1tm2.1(cre)And/Esr1tm2.1(cre)And
involves: C57BL/6 		no abnormal phenotype detected J:101977
Esr1tm2.1Gsc/Esr1tm2.1Gsc
involves: 129P2/OlaHsd * C57BL/6 		abnormal mammary gland development J:152849
female infertility J:152849
ovary hemorrhage J:152849
small uterus J:152849
Esr1tm2Ksk/Esr1tm2Ksk
involves: C57BL/6 		increased circulating luteinizing hormone level J:118736
Esr1tm3.1Ksk/Esr1tm3.1Ksk
involves: 129S6/SvEvTac * C57BL/6 		abnormal mammary gland development J:176459
abnormal ovarian follicle morphology J:176459
abnormal response/metabolism to endogenous compounds J:176459
absent corpus luteum J:176459
absent estrous cycle J:176459
decreased endometrial gland number J:176459
decreased primordial ovarian follicle number J:176459
increased circulating estradiol level J:176459
increased luteinizing hormone level J:176459
small uterus J:176459
uterus cyst J:176459
uterus hypoplasia J:176459
Esr1tm4.2Ksk/Esr1tm4.2Ksk
involves: C57BL/6 * C57BL/6NTac * CBA 		abnormal mammary gland development J:191182
abnormal uterus development J:191182
normal growth/size/body region phenotype J:191182
increased body weight J:191182
increased bone mineral density J:191182
increased circulating luteinizing hormone level J:191182
increased circulating testosterone level J:191182
increased growth rate J:191182
increased total body fat amount J:191182
Esr1tm5.1Ksk/Esr1tm5.1Ksk
involves: 129 * C57BL/6 		abnormal uterus morphology J:263739
absent corpus luteum J:263739
infertility J:263739
testicular atrophy J:263739
uterus hypoplasia J:263739
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
involves: FVB/N 		abnormal branching of the mammary ductal tree J:96383
abnormal mammary gland duct morphology J:96383
abnormal mammary gland epithelium morphology J:96383
abnormal mammary gland lobule morphology J:96383
abnormal mammary gland morphology J:96383
increased mammary gland ductal carcinoma incidence J:96383
mammary gland alveolar hyperplasia J:96383
mammary gland duct hyperplasia J:96383
Tg(MMTVtTA)1Mam/0
Tg(tetO-Esr1)#Paf/0
involves: C57BL/6 * FVB/N * SJL 		abnormal seminal vesicle morphology J:78639
abnormal vas deferens morphology J:78639
decreased epididymis weight J:78639
decreased litter size J:78639
short estrus J:78639
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12/10/2024
MGI 6.24 		The Jackson Laboratory