Bag3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bag3
BCL2-associated athanogene 3
MGI:1352493

45 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Bag3^{Gt(OST16086)Lex}/Bag3^{Gt(OST16086)Lex} involves: 129S5/SvEvBrd * C57BL/6	abnormal skeletal muscle morphology	J:112361
	abnormal Z line morphology	J:112361
	disproportionate dwarf	J:112361
	increased cardiomyocyte apoptosis	J:112361
	myocardial fiber degeneration	J:112361
	postnatal growth retardation	J:112361
	postnatal lethality	J:112361
	pulmonary edema	J:112361
	skeletal muscle fiber degeneration	J:112361
Bag3^tm1.1Chen/Bag3^tm1.1Chen B6.129(SJL)-Bag3^tm1.1Chen	postnatal growth retardation	J:246352
Bag3^tm1.1Chen/Bag3^tm1.1Chen B6.129(SJL)-Bag3^tm1.1Chen	premature death	J:246352
Bag3^tm1.1Jhl/Bag3^tm1.1Jhl B6.129S2-Bag3^tm1.1Jhl	decreased circulating cholesterol level	J:144416
	decreased circulating insulin level	J:144416
	decreased circulating triglyceride level	J:144416
	decreased gonadal fat pad weight	J:144416
	decreased leukocyte cell number	J:144416
	decreased liver weight	J:144416
	decreased lymphocyte cell number	J:144416
	decreased neutrophil cell number	J:144416
	decreased spleen weight	J:144416
	decreased subcutaneous adipose tissue amount	J:144416
	decreased thymus weight	J:144416
	hepatic steatosis	J:144416
	hypoglycemia	J:144416
	increased circulating ketone body level	J:144416
	pale liver	J:144416
	postnatal lethality, complete penetrance	J:144416
	spleen hypoplasia	J:144416
	thymus hypoplasia	J:144416
	weight loss	J:144416
Bag3^{tm1a(EUCOMM)Hmgu}/Bag3⁺ C57BL/6N-Bag3^{tm1a(EUCOMM)Hmgu}/H	increased body weight	J:165965
	increased grip strength	J:165965
Bag3^{tm1b(EUCOMM)Hmgu}/Bag3⁺ C57BL/6N-Bag3^{tm1b(EUCOMM)Hmgu}/H	decreased blood urea nitrogen level	J:211773
Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu} C57BL/6N-Bag3^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773
Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu} involves: C57BL/6N	decreased body weight	J:246352
	postnatal growth retardation	J:246352
	preweaning lethality, complete penetrance	J:246352
Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen Tg(Myhca-cre)1Abel/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N	abnormal heart echocardiography feature	J:246352
	decreased cardiac muscle contractility	J:246352
	dilated cardiomyopathy	J:246352
	enlarged heart	J:246352
	impaired autophagy	J:246352
	increased heart weight	J:246352
Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu} Tg(Myhca-cre)1Abel/0 involves: C57BL/6N * FVB/N	abnormal autophagosome formation	J:246352
	abnormal fetal cardiomyocyte physiology	J:246352
	abnormal heart echocardiography feature	J:246352
	abnormal myocardial fiber physiology	J:246352
	cardiac fibrosis	J:246352
	congestive heart failure	J:246352
	decreased cardiac muscle contractility	J:246352
	dilated cardiomyopathy	J:246352
	enlarged heart	J:246352
	impaired autophagy	J:246352
	increased heart weight	J:246352
	premature death	J:246352

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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