Dtx1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dtx1
deltex 1, E3 ubiquitin ligase
MGI:1352744

32 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dtx1^em1(IMPC)H/Dtx1^em1(IMPC)H C57BL/6N-Dtx1^em1(IMPC)H/H	abnormal locomotor behavior	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	decreased prepulse inhibition	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating glucose level	J:211773
Dtx1^tm1.1Mzl/Dtx1^tm1.1Mzl Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal thymocyte activation	J:151605
	increased anti-double stranded DNA antibody level	J:151605
	increased anti-histone antibody level	J:151605
	increased autoantibody level	J:151605
	increased interleukin-2 secretion	J:151605
	increased T cell proliferation	J:151605
Dtx1^tm1.2Mzl/Dtx1^tm1.2Mzl B6.129-Dtx1^tm1.2Mzl	abnormal lymphocyte morphology	J:151605
	abnormal lymphocyte physiology	J:151605
	abnormal regulatory T cell physiology	J:151605
	abnormal T cell anergy	J:151605
	abnormal thymocyte activation	J:151605
	decreased marginal zone B cell number	J:151605
	decreased thymocyte apoptosis	J:151605
	decreased transforming growth factor beta level	J:151605
	glomerulonephritis	J:151605
	increased anti-double stranded DNA antibody level	J:151605
	increased anti-histone antibody level	J:151605
	increased B cell proliferation	J:151605
	increased interferon-gamma secretion	J:151605
	increased interleukin-2 secretion	J:151605
	increased interleukin-4 secretion	J:151605
	increased T cell proliferation	J:151605
	liver inflammation	J:151605
	lung inflammation	J:151605
	renal glomerular immunoglobulin deposits	J:151605
	spleen hyperplasia	J:151605
Dtx1^tm1Crey/Dtx1^tm1Crey involves: 129P2/OlaHsd	no abnormal phenotype detected	J:95986
Dtx1^tm1Mjb/Dtx1^tm1Mjb either: B6.129S6-Dtx1^tm1Mjb or (involves: 129S6/SvEvTac * C57BL/6)	normal immune system phenotype	J:114658
Tg(Cd4-Dtx1)1Mzl/? involves: C57BL/6	abnormal T cell activation	J:151605
	abnormal thymocyte activation	J:151605
	decreased interleukin-2 secretion	J:151605
	decreased T cell proliferation	J:151605

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24