Eif2ak2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
MGI:1353449

19 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Eif2ak2^em1(IMPC)Mbp/Eif2ak2^em1(IMPC)Mbp C57BL/6N-Eif2ak2^em1(IMPC)Mbp/MbpMmucd	abnormal spleen morphology	J:211773
	increased circulating calcium level	J:211773
	increased circulating creatinine level	J:211773
	increased circulating serum albumin level	J:211773
	small spleen	J:211773
Eif2ak2^tm1Ajs/Eif2ak2^tm1Ajs involves: 129	abnormal cell physiology	J:187314
Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe involves: 129	normal immune system phenotype	J:114555
Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe involves: 129S/SvEv * C57BL/6	increased interleukin-4 secretion	J:66112
	increased susceptibility to Picornaviridae infection	J:30617
	increased susceptibility to type IV hypersensitivity reaction	J:66112
	increased T cell proliferation	J:66112
Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe involves: 129S4/SvJae	decreased sensitivity to induced cell death	J:63671
	normal immune system phenotype	J:63671
	increased sensitivity to induced cell death	J:63671
	increased susceptibility to induced morbidity/mortality	J:63671
	increased susceptibility to Orthomyxoviridae infection	J:63671
	increased susceptibility to Riboviria infection	J:63671, J:167126
Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe involves: 129S4/SvJae * BALB/c	normal cellular phenotype	J:53258
	decreased erythroid progenitor cell number	J:53258
	normal immune system phenotype	J:53258
	normal neoplasm	J:53258

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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