Aldh1a1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
MGI:1353450

27 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aldh1a1^{tm1.1(cre/ERT2)Cai}/Aldh1a1⁺ Slc6a3^{tm1c(KOMP)Wtsi}/Slc6a3^{tm1c(KOMP)Wtsi} involves: C57BL/6N * SJL	abnormal motor coordination/balance	J:280705
	normal behavior/neurological phenotype	J:280705
Aldh1a1^tm1.1Ngb/Aldh1a1^tm1.1Ngb Aldh1a3^tm1.1Pcn/Aldh1a3^tm1.1Pcn involves: 129/Sv * C57BL/6 * SJL	abnormal conjunctival sac morphology	J:102847
	abnormal cornea stroma development	J:102847
	abnormal eyelid development	J:102847
	abnormal nose morphology	J:102847
	absent Harderian gland	J:102847
	absent iris stroma	J:102847
	absent sclera	J:102847
	decreased periocular mesenchyme apoptosis	J:102847
	decreased ventral retina size	J:102847
	neonatal lethality, complete penetrance	J:102847
	persistent hyperplastic primary vitreous	J:102847
	respiratory distress	J:102847
	ventral rotation of lens	J:102847
Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.1Mbp Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal spermatogenesis	J:324715
	azoospermia	J:324715
	male infertility	J:324715
Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ involves: 129 * C57BL/6 * SJL	abnormal spermatogenesis	J:324715
	azoospermia	J:324715
	decreased Sertoli cell number	J:324715
	male infertility	J:324715
Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1.1Mbp/Aldh1a2^tm1.2Mbp Tg(Stra8-icre)1Reb/0 involves: 129 * C57BL/6 * FVB/NJ	normal reproductive system phenotype	J:324715
Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal optic cup morphology	J:108515
Aldh1a1^tm1Gdu/Aldh1a1^tm1Gdu Aldh1a3^tm1Gdu/Aldh1a3^tm1Gdu involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal periocular mesenchyme morphology	J:108515
	abnormal posterior eye segment morphology	J:108515
	abnormal vitreous body morphology	J:108515
	decreased periocular mesenchyme apoptosis	J:108515
	increased cornea stroma thickness	J:108515
	increased total retina thickness	J:108515
	persistent hyperplastic primary vitreous	J:108515
	thick eyelids	J:108515

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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