Akr1b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Akr1b1
aldo-keto reductase family 1 member B
MGI:1353494

18 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab B6.Cg-Akr1b1^tm1.1Kgab	abnormal vitamin C level	J:164548
Akr1b1^tm1Skc/Akr1b1^tm1Skc either: B6.129S7-Akr1b3^tm1Skc or (involves: 129S7/SvEvBrd * C57BL/6N)	abnormal kidney inner medulla morphology	J:77647
	abnormal renal water reabsorption	J:77647
	decreased urine calcium level	J:77647
	decreased urine chloride ion level	J:77647
	decreased urine creatinine level	J:77647
	decreased urine osmolality	J:77647
	decreased urine potassium level	J:77647
	decreased urine sodium level	J:77647
	decreased urine urea nitrogen level	J:77647
	dilated kidney collecting duct	J:77647
	normal homeostasis/metabolism phenotype	J:77647
	polydipsia	J:77647
	polyuria	J:77647
Akr1b1^tm1Tona/Akr1b1^tm1Tona involves: 129S/SvEv * C57BL/6	decreased urine osmolality	J:114187
	increased circulating calcium level	J:114187
	increased circulating magnesium level	J:114187
	increased urine calcium level	J:114187
	polyuria	J:114187
	weight loss	J:114187

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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