Pik3cg Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
MGI:1353576

51 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pik3cg^{tm1a(EUCOMM)Wtsi}/Pik3cg^{tm1a(EUCOMM)Wtsi} B6NTac;B6N-A^tm1Brd Pik3cg^{tm1a(EUCOMM)Wtsi}/WtsiOulu	decreased circulating alanine transaminase level	J:175295
Pik3cg^tm1Dwu/Pik3cg^tm1Dwu B6.Cg-Pik3cg^tm1Dwu	abnormal CD8-positive, alpha-beta T cell physiology	J:131923
	abnormal platelet physiology	J:107460
	abnormal response to infection	J:131923
	decreased CD8-positive, alpha-beta T cell number	J:131923
	decreased platelet aggregation	J:107460
	decreased platelet calcium level	J:107460
	decreased susceptibility to induced thrombosis	J:107460
	normal immune system phenotype	J:131923
	increased susceptibility to induced morbidity/mortality	J:131923
	increased susceptibility to Poxviridae infection	J:131923
	weight loss	J:131923
Pik3cg^tm1Dwu/Pik3cg^tm1Dwu Not Specified	decreased immunoglobulin level	J:60348
Pik3cg^tm1Dwu/Pik3cg^tm1Dwu Not Specified	impaired neutrophil chemotaxis	J:60348
Pik3cg^tm1Ehi/Pik3cg^tm1Ehi Not Specified	abnormal heart ventricle morphology	J:91945
	abnormal myocardial fiber morphology	J:91945
	decreased platelet aggregation	J:152267
	impaired macrophage chemotaxis	J:91945
	impaired neutrophil recruitment	J:91945
Pik3cg^tm1Lste/Pik3cg^tm1Lste involves: 129P2/OlaHsd	impaired neutrophil chemotaxis	J:238900
Pik3cg^tm1Lste/Pik3cg^tm1Lste involves: 129P2/OlaHsd * C57BL/6	abnormal neutrophil physiology	J:147259
	impaired neutrophil chemotaxis	J:147259
	impaired neutrophil recruitment	J:147259
Pik3cg^tm1Pngr/Pik3cg^tm1Pngr B6.129P2-Pik3cg^tm1Pngr	decreased inflammatory response	J:134324
	decreased susceptibility to induced arthritis	J:134324
	impaired neutrophil chemotaxis	J:134324
Pik3cg^tm1Pngr/Pik3cg^tm1Pngr involves: 129P2/OlaHsd	abnormal cardiac muscle relaxation	J:79151
Pik3cg^tm1Pngr/Pik3cg^tm1Pngr involves: 129P2/OlaHsd	increased cardiac muscle contractility	J:79151
Pik3cg^tm1Pngr/Pik3cg^tm1Pngr involves: 129P2/OlaHsd * C57BL/6	abnormal definitive hematopoiesis	J:60347
	abnormal immune cell physiology	J:60347
	abnormal neutrophil physiology	J:60347
	abnormal NK cell differentiation	J:124330
	abnormal T cell activation	J:60347
	abnormal T cell differentiation	J:60347
	abnormal T cell physiology	J:60347
	abnormal T-helper 2 physiology	J:60347
	decreased CD4-positive, alpha-beta T cell number	J:60347
	decreased cytotoxic T cell cytolysis	J:124330
	decreased interferon-gamma secretion	J:60347, J:124330
	decreased interleukin-2 secretion	J:60347
	decreased T cell proliferation	J:60347
	decreased thymocyte number	J:60347
	impaired neutrophil chemotaxis	J:60347
	impaired neutrophil recruitment	J:60347
	increased eosinophil cell number	J:60347
	increased monocyte cell number	J:60347
	increased neutrophil cell number	J:60347
	thymus hypoplasia	J:60347
Pik3cg^tm1Wym/Pik3cg^tm1Wym either: 129/Sv-Pik3cg^tm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal leukocyte physiology	J:60349
	abnormal neutrophil physiology	J:60349
	impaired macrophage chemotaxis	J:60349
	impaired neutrophil chemotaxis	J:60349
	impaired neutrophil recruitment	J:60349
	increased neutrophil cell number	J:60349
	increased susceptibility to bacterial infection	J:60349
Pik3cg^tm1Wym/Pik3cg^tm1Wym involves: 129S1/Sv * 129X1/SvJ	abnormal neutrophil physiology	J:147259
	impaired neutrophil chemotaxis	J:238900
	impaired neutrophil recruitment	J:147259
	increased cardiac muscle contractility	J:79151
Pik3cg^tm2Ehi/Pik3cg^tm2Ehi Not Specified	abnormal inflammatory response	J:124856
	abnormal macrophage physiology	J:124856
	decreased macrophage cell number	J:124856
	decreased neutrophil cell number	J:124856
	impaired macrophage chemotaxis	J:124856
	impaired neutrophil chemotaxis	J:124856
	increased interleukin-1 beta secretion	J:124856
	increased interleukin-6 secretion	J:124856
	increased leukocyte cell number	J:124856
	increased tumor necrosis factor secretion	J:124856
	skin lesions	J:124856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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