Pik3cg Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
MGI:1353576

27 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ace2^tm1Pngr/Y Pik3cg^tm1Pngr/Pik3cg^tm1Pngr involves: 129P2/OlaHsd * C57BL/6	increased cardiac muscle contractility	J:124548
Apoe^tm1Unc/Apoe^tm1Unc Pik3cg^tm1Dwu/Pik3cg^tm1Dwu B6.Cg-Apoe^tm1Unc Pik3cg^tm1Dwu	atherosclerotic lesions	J:121582
	decreased circulating cholesterol level	J:121582
Pik3cd^tm1Jni/Pik3cd^tm1Jni Pik3cg^tm1Pngr/Pik3cg^tm1Pngr involves: 129P2/OlaHsd * C57BL/6	abnormal NK cell differentiation	J:124330
	decreased cytotoxic T cell cytolysis	J:124330
	decreased interferon-gamma secretion	J:124330
	decreased NK cell number	J:124330
	decreased T cell number	J:124330
	spleen hypoplasia	J:124330
Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pik3cg^tm1Pngr/Pik3cg^tm1Pngr B6.129-Pik3cd^tm1Tnr Pik3cg^tm1Pngr	decreased inflammatory response	J:134324
	decreased susceptibility to induced arthritis	J:134324
	impaired neutrophil chemotaxis	J:134324
	impaired neutrophil recruitment	J:134324
Pik3cd^tm1Tnr/Pik3cd^tm1Tnr Pik3cg^tm1Pngr/Pik3cg^tm1Pngr involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal T cell differentiation	J:125791
	abnormal T cell physiology	J:125791
	abnormal thymus lobule morphology	J:125791
	decreased CD4-positive, alpha-beta T cell number	J:125791
	decreased CD8-positive, alpha-beta T cell number	J:125791
	decreased double-positive T cell number	J:125791
	decreased lymphocyte cell number	J:125791
	decreased T cell number	J:125791
	small thymus	J:125791
	thymus hypoplasia	J:125791
Pik3cg^tm1Dwu/Pik3cg^tm1Dwu Tg(TcraTcrb)1100Mjb/0 involves: C57BL/6	abnormal CD8-positive, alpha-beta T cell physiology	J:131923
	abnormal response to infection	J:131923
	normal immune system phenotype	J:131923
Pik3cg^tm1Pngr/Pik3cg^tm1Pngr Pten^tm2Mak/Pten^tm2Mak Tg(Ckmm-cre)5Khn/0 involves: 129P2/OlaHsd * FVB	cardiac hypertrophy	J:79151
	enlarged heart	J:79151
	increased cardiac muscle contractility	J:79151

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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