Gnl3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gnl3
guanine nucleotide binding protein nucleolar 3
MGI:1353651

30 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gnl3^{Gt(S4-4B1)Sor}/Gnl3^{Gt(S4-4B1)Sor} involves: 129S4/SvJaeSor * C57BL/6	absent blastocoele	J:185271
	absent inner cell mass	J:185271
	absent trophectoderm	J:185271
	decreased cell proliferation	J:185271
	embryonic growth retardation	J:185271
	embryonic lethality, complete penetrance	J:185271
	increased apoptosis	J:185271
Gnl3^{Gt(W223E05)Wrst}/Gnl3⁺ Not Specified	decreased cell proliferation	J:118144
Gnl3^{Gt(W223E05)Wrst}/Gnl3^{Gt(W223E05)Wrst} Not Specified	abnormal blastocyst morphology	J:118144
	abnormal cell cycle	J:118144
	decreased cell proliferation	J:118144
	embryonic growth arrest	J:118144
	embryonic lethality before implantation, incomplete penetrance	J:118144
	embryonic lethality between implantation and somite formation, complete penetrance	J:118144
	failure of blastocyst to hatch from the zona pellucida	J:118144
Gnl3^tm1Rylt/Gnl3⁺ involves: 129X1/SvJ * C57BL/6	abnormal cell cycle	J:117592
	decreased fibroblast proliferation	J:117592
	early cellular replicative senescence	J:117592
	increased fibroblast apoptosis	J:117592
Gnl3^tm1Rylt/Gnl3^tm1Rylt involves: 129X1/SvJ * C57BL/6	embryonic lethality before implantation, complete penetrance	J:117592
Gnl3^tm2.1Rylt/Gnl3^tm2.1Rylt Tg(CAG-cre/Esr1)5Amc/0 involves: 129 129S2/SvPas * C57BL/6 * CBA	abnormal cell physiology	J:198698
	decreased fibroblast proliferation	J:198698
Gnl3^tm2.1Rylt/Gnl3^tm2.1Rylt Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * CBA	abnormal brain morphology	J:198698
	abnormal cerebellum development	J:198698
	abnormal diencephalon morphology	J:198698
	abnormal embryonic neuroepithelium morphology	J:198698
	abnormal embryonic/fetal subventricular zone morphology	J:198698
	abnormal neuronal stem cell morphology	J:198698
	abnormal tectum morphology	J:198698
	abnormal telencephalon morphology	J:198698
	decreased spinal cord size	J:198698
	decreased tegmentum size	J:198698
	neonatal lethality, complete penetrance	J:198698
	respiratory failure	J:198698
Gnl3^tm2.2Rylt/Gnl3^tm2.2Rylt involves: 129 * FVB/N	embryonic lethality before implantation, complete penetrance	J:198698

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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