Glrx3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Glrx3
glutaredoxin 3
MGI:1353653

26 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Glrx3^{Gt(RRF094)Byg}/Glrx3⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal cardiac muscle relaxation	J:143577
	abnormal myocardial fiber physiology	J:143577
	decreased cardiac muscle contractility	J:143577
	increased response of heart to induced stress	J:143577
Glrx3^{Gt(RRF094)Byg}/Glrx3^{Gt(RRF094)Byg} involves: 129P2/OlaHsd * C57BL/6	abnormal cell cycle	J:190794
	abnormal cell death	J:190794
	binucleate	J:190794
	decreased embryo size	J:143577, J:190794
	decreased fibroblast proliferation	J:190794
	embryonic lethality during organogenesis, complete penetrance	J:190794
	embryonic lethality during organogenesis, incomplete penetrance	J:143577
	intracranial hemorrhage	J:143577
	lethality throughout fetal growth and development, complete penetrance	J:143577
	open neural tube	J:190794
	pericardial effusion	J:190794
Glrx3^{tm1.1(KOMP)Vlcg}/Glrx3⁺ B6N(Cg)-Glrx3^{tm1.1(KOMP)Vlcg}/J	increased circulating alkaline phosphatase level	J:211773
Glrx3^{tm1.1(KOMP)Vlcg}/Glrx3^{tm1.1(KOMP)Vlcg} B6N(Cg)-Glrx3^{tm1.1(KOMP)Vlcg}/J	absent head fold	J:279207
	absent primitive node	J:279207
	decreased egg cylinder size	J:279207
	decreased embryo size	J:279207
	embryonic growth arrest	J:279207
	embryonic lethality between implantation and placentation, complete penetrance	J:279207
	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	failure of primitive streak formation	J:279207
	failure to gastrulate	J:279207
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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