Sirt6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirt6
sirtuin 6
MGI:1354161

56 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sirt6^tm1.1Cxd/Sirt6^tm1.1Cxd Tg(Alb1-cre)1Dlr/0 involves: 129S6/SvEvTac * FVB/N	abnormal liver morphology	J:166368
	hepatic steatosis	J:166368
	increased circulating glucose level	J:166368
	increased liver weight	J:166368
Sirt6^{tm1a(EUCOMM)Wtsi}/Sirt6⁺ C57BL/6N-Sirt6^{tm1a(EUCOMM)Wtsi}/H	increased circulating cholesterol level	J:165965
	increased mean corpuscular hemoglobin concentration	J:165965
Sirt6^tm1Fwa/Sirt6^tm1Fwa involves: 129S6/SvEvTac * 129X1/SvJ	abnormal B cell differentiation	J:112817
	abnormal lymphopoiesis	J:112817
	colitis	J:112817
	decreased body length	J:229077
	decreased body size	J:112817
	decreased body weight	J:229077
	decreased bone marrow cell number	J:112817
	decreased bone mineral density	J:112817
	decreased cell proliferation	J:112817
	decreased circulating glucose level	J:112817
	decreased circulating insulin-like growth factor I level	J:112817
	decreased double-positive T cell number	J:112817
	decreased leukocyte cell number	J:112817
	decreased subcutaneous adipose tissue amount	J:112817
	increased cellular sensitivity to alkylating agents	J:112817
	increased cellular sensitivity to ionizing radiation	J:112817
	lethality at weaning, complete penetrance	J:112817
	lordokyphosis	J:112817
	postnatal growth retardation	J:112817
	spleen hypoplasia	J:112817
	spontaneous chromosome breakage	J:112817
Sirt6^tm1Fwa/Sirt6^tm1Fwa involves: 129S6/SvEvTac * BALB/cJ	abnormal cornea physiology	J:247143
	abnormal cornea stroma morphology	J:247143
	abnormal electroretinogram waveform feature	J:247143
	cornea scarring	J:247143
	cornea vascularization	J:247143
	decreased a-wave amplitude	J:247143
	decreased b-wave amplitude	J:247143
	decreased body weight	J:247143
	decreased circulating insulin level	J:247143
	decreased subcutaneous adipose tissue amount	J:247143
	normal homeostasis/metabolism phenotype	J:247143
	impaired glucose tolerance	J:247143
	increased cornea thickness	J:247143
	increased susceptibility to age-related retinal degeneration	J:247143
	premature death	J:247143
	prenatal lethality, incomplete penetrance	J:247143
	thin retina inner nuclear layer	J:247143
	thin retina outer nuclear layer	J:247143
Sirt6^tm2.1Cxd/Sirt6^tm2.1Cxd involves: 129S6/SvEvTac * NIH Black Swiss	abnormal eye morphology	J:167023
	abnormal glucose homeostasis	J:167023
	abnormal nursing	J:167023
	abnormal spleen physiology	J:167023
	decreased body size	J:167023
	decreased body weight	J:167023
	decreased bone mineral density	J:167023
	decreased circulating glucose level	J:167023
	decreased circulating insulin level	J:167023
	decreased subcutaneous adipose tissue amount	J:167023
	decreased total body fat amount	J:167023
	early cellular replicative senescence	J:167023
	hypoglycemia	J:167023
	increased insulin sensitivity	J:167023
	lordokyphosis	J:167023
	male infertility	J:167023
	malocclusion	J:167023
	narrow eye opening	J:167023
	premature aging	J:167023
	premature death	J:167023
	reduced female fertility	J:167023
Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss	abnormal eye morphology	J:167023
	abnormal glucose homeostasis	J:167023
	abnormal nursing	J:167023
	abnormal spleen physiology	J:167023
	decreased body size	J:167023
	decreased body weight	J:167023
	decreased bone mineral density	J:167023
	decreased circulating glucose level	J:167023
	decreased circulating insulin level	J:167023
	decreased subcutaneous adipose tissue amount	J:167023
	decreased total body fat amount	J:167023
	early cellular replicative senescence	J:167023
	hypoglycemia	J:167023
	increased insulin sensitivity	J:167023
	lordokyphosis	J:167023
	male infertility	J:167023
	malocclusion	J:167023
	narrow eye opening	J:167023
	premature aging	J:167023
	premature death	J:167023
	reduced female fertility	J:167023

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24