Sirt6 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirt6
sirtuin 6
MGI:1354161

7 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd Trp53^tm1Brd/Trp53^tm1Brd involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N * NIH Black Swiss	decreased body weight	J:167023
	decreased circulating glucose level	J:167023
	premature death	J:167023
Tg(RP23-352G18)1Coppa/0 C57BL/6-Tg(RP23-352G18)1Coppa	decreased circulating glucose level	J:229077
	decreased susceptibility to diet-induced non-insulin dependent diabetes	J:229077
	decreased susceptibility to diet-induced obesity	J:229077
	improved glucose tolerance	J:229077
	increased insulin sensitivity	J:229077

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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