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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Txnrd1
thioredoxin reductase 1
MGI:1354175
40 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl2tm1(cre)Krc/Myl2+
Txnrd1tm1Marc/Txnrd1tm1.1Marc
involves: 129P2/OlaHsd * C57BL/6J 		normal cardiovascular system phenotype J:96818
Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
B6.129X1-Txnrd1tm1.1Ees 		abnormal embryonic tissue morphology J:124356
abnormal visceral endoderm morphology J:124356
absent embryonic epiblast J:124356
embryonic growth arrest J:124356
embryonic lethality between somite formation and embryo turning, complete penetrance J:124356
failure of primitive streak formation J:124356
failure to gastrulate J:124356
increased trophoblast giant cell number J:124356
Txnrd1tm1.1Marc/Txnrd1tm1.1Marc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal neural tube morphology J:96818
abnormal visceral yolk sac morphology J:96818
absent fibroblast proliferation J:96818
decreased cell proliferation J:96818
decreased embryo size J:96818
embryonic growth arrest J:96818
embryonic lethality during organogenesis, complete penetrance J:96818
failure of initiation of embryo turning J:96818
impaired somite development J:96818
short rostral-caudal axis J:96818
Txnrd1tm1Ees/Txnrd1tm1Ees
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:124356
Txnrd1tm1Marc/Txnrd1tm1Marc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal astrocyte morphology J:133173
abnormal cerebellar cortex morphology J:133173
abnormal cerebellar lobule formation J:133173
abnormal cerebellum development J:133173
abnormal cerebellum morphology J:133173
abnormal gait J:133173
abnormal glial cell morphology J:133173
abnormal Purkinje cell dendrite morphology J:133173
ataxia J:133173
cerebellum hypoplasia J:133173
decreased body size J:133173
ectopic Purkinje cell J:133173
impaired balance J:133173
impaired coordination J:133173
normal nervous system phenotype J:133173
normal reproductive system phenotype J:133173
slow postnatal weight gain J:133173
thin external granule cell layer J:133173
tremors J:133173
Txnrd1tm1Marc/Txnrd1tm1Marc
Tg(Tuba1-cre)1Tes/0
involves: 129P2/OlaHsd 		normal behavior/neurological phenotype J:133173
normal growth/size/body region phenotype J:133173
normal nervous system phenotype J:133173
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory