Nox4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nox4
NADPH oxidase 4
MGI:1354184

39 phenotypes from 10 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nox4^em1(IMPC)Mbp/Nox4^em1(IMPC)Mbp C57BL/6N-Nox4^em1(IMPC)Mbp/MbpMmucd	abnormal lymph node morphology	J:211773
	enlarged lymph nodes	J:211773
	increased circulating creatinine level	J:211773
Nox4^tm1.1Ams/Nox4^tm1.1Ams B6.129-Nox4^tm1.1Ams	abnormal kidney physiology	J:165541
	cardiac hypertrophy	J:165541
	cardiac interstitial fibrosis	J:165541
	dilated heart	J:165541
	increased response of heart to induced stress	J:165541
Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc involves: 129P2/OlaHsd * C57BL/6	normal cardiovascular system phenotype	J:166948
	decreased cerebral infarct size	J:166948
	decreased neuron apoptosis	J:166948
	decreased susceptibility to ischemic brain injury	J:166948
	enhanced blood-brain barrier function	J:166948
	oxidative stress	J:166948
Nox4^tm1.1Jusa/Nox4^tm1.1Jusa Tg(Myh6-cre)2182Mds/0 involves: C57BL/6 * FVB	abnormal mitochondrial physiology	J:163751
	cardiac interstitial fibrosis	J:163751
	decreased cardiomyocyte apoptosis	J:163751
	decreased heart left ventricle muscle contractility	J:163751
	decreased heart ventricle muscle contractility	J:163751
	decreased response of heart to induced stress	J:163751
	decreased susceptibility to induced morbidity/mortality	J:163751
	heart left ventricle hypertrophy	J:163751
	oxidative stress	J:163751
Nox4^tm1Kkr/Nox4^tm1Kkr B6.129-Nox4^tm1Kkr	abnormal lung morphology	J:199354
	decreased apoptosis	J:199354
	decreased physiological sensitivity to xenobiotic	J:199354
	decreased susceptibility to weight loss	J:199354
	oxidative stress	J:199354
Nox4^tm1Syb/Nox4^tm1Syb involves: 129S4/SvJae	abnormal response/metabolism to endogenous compounds	J:298830
	decreased interleukin-1 beta secretion	J:298830
	decreased kidney apoptosis	J:298830
	decreased renal tubule apoptosis	J:298830
	decreased susceptibility to endotoxin shock	J:298830
	decreased susceptibility to induced morbidity/mortality	J:298830
	decreased tumor necrosis factor secretion	J:298830
Nox4^tm1Syb/Nox4^tm1Syb involves: 129S4/SvJae * C57BL/6N	abnormal redox activity	J:218649
Tg(Myh6-Nox4)1Ams/0 B6.Cg-Tg(Myh6-Nox4)1Ams	abnormal cardiovascular system physiology	J:165541
	decreased response of heart to induced stress	J:165541
	increased heart left ventricle weight	J:165541
	increased heart weight	J:165541
	thick interventricular septum	J:165541
Tg(Myh6-Nox4)3Jusa/0 FVB-Tg(Myh6-Nox4)3Jusa	cardiac hypertrophy	J:163751
Tg(Myh6-Nox4)13Jusa/0 FVB-Tg(Myh6-Nox4)13Jusa	cardiac hypertrophy	J:163751
Tg(Myh6-Nox4)#Jusa/0 FVB-Tg(Myh6-Nox4)#Jusa	abnormal mitochondrial physiology	J:163751
	abnormal ventricle myocardium morphology	J:163751, J:164275
	cardiac fibrosis	J:163751
	cardiac interstitial fibrosis	J:164275
	decreased heart ventricle muscle contractility	J:163751, J:164275
	increased cardiomyocyte apoptosis	J:163751, J:164275
	oxidative stress	J:163751

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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