Lats2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lats2
large tumor suppressor 2
MGI:1354386

27 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lats2^tm1.1Dupa/Lats2^tm1.1Dupa involves: 129P2/OlaHsd	no abnormal phenotype detected	J:223215
Lats2^tm1.1Jfm/Lats2^tm1.1Jfm involves: 129S6/SvEvTac * C57BL/6Brd * CD-1	no abnormal phenotype detected	J:101977
Lats2^tm1Dgen/Lats2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal startle reflex	J:101679
Lats2^tm1Dgen/Lats2^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:101679
Lats2^tm1Noj/Lats2⁺ involves: 129S2/SvPas * C57BL/6	prenatal lethality, complete penetrance	J:123480
Lats2^tm1Noj/Lats2^tm1Noj involves: 129S2/SvPas	abnormal centrosome morphology	J:200232
Lats2^tm1Noj/Lats2^tm1Noj involves: 129S2/SvPas * C57BL/6	abnormal cell nucleus morphology	J:123480
	abnormal fourth ventricle morphology	J:123480
	abnormal intracellular organelle morphology	J:123480
	abnormal mitosis	J:123480
	abnormal pharyngeal arch morphology	J:123480
	abnormal spinal cord morphology	J:123480
	decreased embryo size	J:123480
	delayed muscle development	J:123480
	embryonic growth retardation	J:123480
	embryonic lethality during organogenesis, complete penetrance	J:123480
	increased cell nucleus count	J:123480
	increased spinal cord apoptosis	J:123480
	polyploidy	J:123480
	small heart	J:123480
Lats2^tm1Raz/Lats2^tm1Raz involves: 129P2/OlaHsd * C57BL/6	abnormal cell proliferation	J:93191
	abnormal heart atrium morphology	J:93191
	chromosome breakage	J:93191
	decreased cell proliferation	J:93191
	embryonic growth retardation	J:93191
	embryonic lethality during organogenesis, complete penetrance	J:93191
	hemopericardium	J:93191
	hemorrhage	J:93191
	trabecula carnea hypoplasia	J:93191
	ventricular hypoplasia	J:93191
	wavy neural tube	J:93191

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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