About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695
96 phenotypes from 11 alleles in 14 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Tg(En2-cre)22Alj/0
Not Specified 		abnormal cerebellar foliation J:176598
abnormal cerebellum fissure morphology J:176598
abnormal neuron differentiation J:176598
abnormal Purkinje cell morphology J:176598
cerebellum vermis hypoplasia J:176598
decreased Purkinje cell number J:176598
decreased Purkinje cell size J:176598
normal nervous system phenotype J:176598
small cerebellum J:176598
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal brain development J:166928
abnormal cerebellum development J:166928
abnormal cerebral cortex morphology J:166928
abnormal cortical intermediate zone morphology J:166928
abnormal cortical plate morphology J:166928
abnormal embryonic/fetal subventricular zone morphology J:166928
abnormal neuron differentiation J:166928
abnormal tectum morphology J:166928
decreased neuronal precursor cell number J:166928
normal nervous system phenotype J:166928
perinatal lethality J:166928
thalamus hypoplasia J:166928
Fbxw7tm1.1Iken/Fbxw7+
involves: C57BL/6 * C57BL/6N 		abnormal respiratory system physiology J:258194
cleft palate J:258194
eyelids open at birth J:258194
perinatal lethality, complete penetrance J:258194
respiratory failure J:258194
thick pulmonary interalveolar septum J:258194
Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
involves: 129P2/OlaHsd * C57BL/6 		abnormal vascular development J:128523
prenatal lethality, complete penetrance J:128523
Fbxw7tm1.2Axbe/Fbxw7tm1.2Axbe
Not Specified 		embryonic lethality, complete penetrance J:176598
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Amh-cre)8815Reb/0
involves: 129 * C57BL/6 * C57BL/6J * FVB/N 		abnormal epididymis morphology J:289161
abnormal male germ cell physiology J:289161
abnormal seminiferous tubule epithelium morphology J:289161
abnormal Sertoli cell barrier morphology J:289161
abnormal Sertoli cell morphology J:289161
abnormal testis development J:289161
arrest of spermatogenesis J:289161
decreased circulating testosterone level J:289161
decreased epididymis weight J:289161
decreased litter size J:289161
decreased male germ cell number J:289161
decreased Sertoli cell number J:289161
decreased testis weight J:289161
ectopic Sertoli cells J:289161
increased male germ cell apoptosis J:289161
male infertility J:289161
oligozoospermia J:289161
reduced male fertility J:289161
seminiferous tubule degeneration J:289161
small epididymis J:289161
small testis J:289161
testicular atrophy J:289161
testis degeneration J:289161
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Lck-cre)1Cwi/0
involves: 129/Sv * C57BL/6 		normal immune system phenotype J:137138
increased T cell derived lymphoma incidence J:137138
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA 		abnormal hematopoietic stem cell physiology J:200006
abnormal T cell differentiation J:200006
decreased hematopoietic stem cell number J:200006
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA 		abnormal T cell differentiation J:137138
decreased bone marrow cell number J:137138
decreased double-negative T cell number J:137138
decreased hematopoietic stem cell number J:137138
thymus hypoplasia J:137138
Fbxw7tm1Iken/Fbxw7tm1Iken
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6N * DBA 		bile duct hyperplasia J:258194
dilated bile duct J:258194
Fbxw7tm1Itom/Fbxw7+
Tg(Pgk1-cre)1Lni/0
involves: 129 * BALB/c * C57BL/6 * C57BL/6J 		cleft palate J:172214
eyelids open at birth J:172214
impaired lung alveolus development J:172214
neonatal lethality, complete penetrance J:172214
thick pulmonary interalveolar septum J:172214
Fbxw7tm1Kei/Fbxw7tm1Kei
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:128523
Fbxw7tm1Kei/Fbxw7tm1Kei
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 		increased double-positive T cell number J:128523
Fbxw7tm1Kei/Fbxw7tm1Kei
Tg(Lck-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell activation J:128523
arrested T cell differentiation J:128523
decreased single-positive T cell number J:128523
enlarged thymus J:128523
increased double-positive T cell number J:128523
increased lymphoma incidence J:128523
increased T cell apoptosis J:128523
premature death J:128523
Fbxw7tm1Kin/Fbxw7tm1Kin
involves: C57BL/6 		abnormal brain vasculature morphology J:88517
abnormal neural tube closure J:88517
abnormal somite border morphology J:88517
abnormal somite development J:88517
abnormal vascular development J:88517
abnormal vasculogenesis J:88517
abnormal vitelline vascular remodeling J:88517
decreased angiogenesis J:88517
embryonic growth retardation J:88517
embryonic lethality during organogenesis, complete penetrance J:88517
intracranial hemorrhage J:88517
pallor J:88517
pericardial edema J:88517
Fbxw7tm1Sje/Fbxw7+
involves: 129S7/SvEvBrd * C57BL/6 		normal neoplasm J:88903
Fbxw7tm1Sje/Fbxw7tm1Sje
involves: 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:88903
abnormal brain development J:88903
abnormal erythrocyte cell number J:88903
abnormal heart development J:88903
decreased embryo size J:88903
disorganized yolk sac vascular plexus J:88903
embryonic growth retardation J:88903
embryonic lethality during organogenesis, complete penetrance J:88903
open neural tube J:88903
pale yolk sac J:88903
Fbxw7tm2Iaai/Fbxw7+
Tg(EIIa-cre)C5379Lmgd/0
involves: C57BL/6 * FVB/N 		normal embryo phenotype J:200006
normal neoplasm J:200006
Fbxw7tm2Iaai/Fbxw7+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		decreased tumor latency J:200006
normal hematopoietic system phenotype J:200006
normal immune system phenotype J:200006
normal neoplasm J:200006
Fbxw7tm2Iaai/Fbxw7tm2Iaai
involves: C57BL/6 		lethality, complete penetrance J:200006
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory