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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695
96 phenotypes from 11 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Tg(En2-cre)22Alj/0
Not Specified 		abnormal cerebellar foliation J:176598
abnormal cerebellum fissure morphology J:176598
abnormal neuron differentiation J:176598
abnormal Purkinje cell morphology J:176598
cerebellum vermis hypoplasia J:176598
decreased Purkinje cell number J:176598
decreased Purkinje cell size J:176598
normal nervous system phenotype J:176598
small cerebellum J:176598
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal brain development J:166928
abnormal cerebellum development J:166928
abnormal cerebral cortex morphology J:166928
abnormal cortical intermediate zone morphology J:166928
abnormal cortical plate morphology J:166928
abnormal embryonic/fetal subventricular zone morphology J:166928
abnormal neuron differentiation J:166928
abnormal tectum morphology J:166928
decreased neuronal precursor cell number J:166928
normal nervous system phenotype J:166928
perinatal lethality J:166928
thalamus hypoplasia J:166928
Fbxw7tm1.1Iken/Fbxw7+
involves: C57BL/6 * C57BL/6N 		abnormal respiratory system physiology J:258194
cleft palate J:258194
eyelids open at birth J:258194
perinatal lethality, complete penetrance J:258194
respiratory failure J:258194
thick pulmonary interalveolar septum J:258194
Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
involves: 129P2/OlaHsd * C57BL/6 		abnormal vascular development J:128523
prenatal lethality, complete penetrance J:128523
Fbxw7tm1.2Axbe/Fbxw7tm1.2Axbe
Not Specified 		embryonic lethality, complete penetrance J:176598
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Amh-cre)8815Reb/0
involves: 129 * C57BL/6 * C57BL/6J * FVB/N 		abnormal epididymis morphology J:289161
abnormal male germ cell physiology J:289161
abnormal seminiferous tubule epithelium morphology J:289161
abnormal Sertoli cell barrier morphology J:289161
abnormal Sertoli cell morphology J:289161
abnormal testis development J:289161
arrest of spermatogenesis J:289161
decreased circulating testosterone level J:289161
decreased epididymis weight J:289161
decreased litter size J:289161
decreased male germ cell number J:289161
decreased Sertoli cell number J:289161
decreased testis weight J:289161
ectopic Sertoli cells J:289161
increased male germ cell apoptosis J:289161
male infertility J:289161
oligozoospermia J:289161
reduced male fertility J:289161
seminiferous tubule degeneration J:289161
small epididymis J:289161
small testis J:289161
testicular atrophy J:289161
testis degeneration J:289161
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Lck-cre)1Cwi/0
involves: 129/Sv * C57BL/6 		normal immune system phenotype J:137138
increased T cell derived lymphoma incidence J:137138
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA 		abnormal hematopoietic stem cell physiology J:200006
abnormal T cell differentiation J:200006
decreased hematopoietic stem cell number J:200006
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA 		abnormal T cell differentiation J:137138
decreased bone marrow cell number J:137138
decreased double-negative T cell number J:137138
decreased hematopoietic stem cell number J:137138
thymus hypoplasia J:137138
Fbxw7tm1Iken/Fbxw7tm1Iken
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6N * DBA 		bile duct hyperplasia J:258194
dilated bile duct J:258194
Fbxw7tm1Itom/Fbxw7+
Tg(Pgk1-cre)1Lni/0
involves: 129 * BALB/c * C57BL/6 * C57BL/6J 		cleft palate J:172214
eyelids open at birth J:172214
impaired lung alveolus development J:172214
neonatal lethality, complete penetrance J:172214
thick pulmonary interalveolar septum J:172214
Fbxw7tm1Kei/Fbxw7tm1Kei
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:128523
Fbxw7tm1Kei/Fbxw7tm1Kei
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 		increased double-positive T cell number J:128523
Fbxw7tm1Kei/Fbxw7tm1Kei
Tg(Lck-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal T cell activation J:128523
arrested T cell differentiation J:128523
decreased single-positive T cell number J:128523
enlarged thymus J:128523
increased double-positive T cell number J:128523
increased lymphoma incidence J:128523
increased T cell apoptosis J:128523
premature death J:128523
Fbxw7tm1Kin/Fbxw7tm1Kin
involves: C57BL/6 		abnormal brain vasculature morphology J:88517
abnormal neural tube closure J:88517
abnormal somite border morphology J:88517
abnormal somite development J:88517
abnormal vascular development J:88517
abnormal vasculogenesis J:88517
abnormal vitelline vascular remodeling J:88517
decreased angiogenesis J:88517
embryonic growth retardation J:88517
embryonic lethality during organogenesis, complete penetrance J:88517
intracranial hemorrhage J:88517
pallor J:88517
pericardial edema J:88517
Fbxw7tm1Sje/Fbxw7+
involves: 129S7/SvEvBrd * C57BL/6 		normal neoplasm J:88903
Fbxw7tm1Sje/Fbxw7tm1Sje
involves: 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:88903
abnormal brain development J:88903
abnormal erythrocyte cell number J:88903
abnormal heart development J:88903
decreased embryo size J:88903
disorganized yolk sac vascular plexus J:88903
embryonic growth retardation J:88903
embryonic lethality during organogenesis, complete penetrance J:88903
open neural tube J:88903
pale yolk sac J:88903
Fbxw7tm2Iaai/Fbxw7+
Tg(EIIa-cre)C5379Lmgd/0
involves: C57BL/6 * FVB/N 		normal embryo phenotype J:200006
normal neoplasm J:200006
Fbxw7tm2Iaai/Fbxw7+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		decreased tumor latency J:200006
normal hematopoietic system phenotype J:200006
normal immune system phenotype J:200006
normal neoplasm J:200006
Fbxw7tm2Iaai/Fbxw7tm2Iaai
involves: C57BL/6 		lethality, complete penetrance J:200006
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/03/2024
MGI 6.24 		The Jackson Laboratory