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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fbxw7
F-box and WD-40 domain protein 7
MGI:1354695
13 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm2.1Wag/Juntm4Wag
Tg(En2-cre)22Alj/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal Purkinje cell morphology J:176598
small cerebellum J:176598
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm4Wag/Jun+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal neuron apoptosis J:166928
abnormal tectum morphology J:166928
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm4Wag/Juntm4Wag
Tg(En2-cre)22Alj/0
involves: 129P2/OlaHsd 		abnormal cerebellum fissure morphology J:176598
abnormal Purkinje cell morphology J:176598
small cerebellum J:176598
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Notch1tm1Agt/Notch1+
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		abnormal neuron differentiation J:166928
Fbxw7tm1Iken/Fbxw7+
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA 		bile duct hyperplasia J:258194
dilated bile duct J:258194
Fbxw7tm1Iken/Fbxw7tm1Iken
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA 		increased cholangiocarcinoma incidence J:258194
Fbxw7tm1Kei/Fbxw7tm1Kei
Myctm2Fwa/Myctm2Fwa
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 		normal immune system phenotype J:128523
Fbxw7tm1Kei/Fbxw7tm1Kei
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		increased double-positive T cell number J:128523
Fbxw7tm1Kei/Fbxw7tm1Kei
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Lck-cre)1Cwi/?
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		normal immune system phenotype J:128523
increased lymphoma incidence J:128523
increased T cell derived lymphoma incidence J:128523
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory