Icosl Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Icosl
icos ligand
MGI:1354701

27 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Icosl^tm1Cdon/Icosl^tm1Cdon involves: 129S6/SvEvTac	abnormal immunoglobulin level	J:86697
	abnormal interferon level	J:86697
	abnormal interleukin secretion	J:86697
	abnormal T cell differentiation	J:86697
	abnormal T-helper 2 physiology	J:86697
	decreased IgE level	J:86697
	decreased IgG1 level	J:86697
	decreased IgG2a level	J:86697
	decreased IgG level	J:86697
	decreased IgM level	J:86697
	small spleen	J:86697
Icosl^tm1Kplm/Icosl^tm1Kplm involves: 129P2/OlaHsd	abnormal humoral immune response	J:84893
	abnormal immune serum protein physiology	J:84893
	abnormal spleen germinal center morphology	J:84893
	decreased IgA level	J:84893
	decreased IgG2a level	J:84893
	decreased IgG2b level	J:84893
	decreased interleukin-4 secretion	J:84893
	decreased interleukin-10 secretion	J:84893
	increased interferon-gamma secretion	J:84893
Icosl^tm1Mak/Icosl^tm1Mak involves: 129P2/OlaHsd * C57BL/6	abnormal class switch recombination	J:84668
	abnormal immune system physiology	J:84668
	abnormal spleen morphology	J:84668
	abnormal T-helper 2 cell differentiation	J:84668
	decreased IgG1 level	J:84668
	decreased inflammatory response	J:84668
	decreased spleen germinal center number	J:84668
	decreased spleen germinal center size	J:84668
	normal immune system phenotype	J:84668

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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