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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pnpla6
patatin-like phospholipase domain containing 6
MGI:1354723
45 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pnpla6tm1Blw/Pnpla6+
involves: 129S6/SvEvTac * C57BL/6J 		normal behavior/neurological phenotype J:82791
hyperactivity J:82791
increased locomotor activity J:82791
increased susceptibility to xenobiotic induced morbidity/mortality J:82791
increased vertical activity J:82791
Pnpla6tm1Blw/Pnpla6tm1Blw
involves: 129S6/SvEvTac * C57BL/6J 		abnormal neural tube closure J:82791
decreased embryo size J:82791
embryonic growth arrest J:82791
embryonic growth retardation J:82791
embryonic lethality during organogenesis, complete penetrance J:82791
Pnpla6tm1Mos/Pnpla6tm1Mos
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal chorion morphology J:87675
abnormal chorionic plate morphology J:87675
abnormal embryo development J:87675
abnormal embryonic tissue morphology J:87675
abnormal extraembryonic tissue morphology J:87675
abnormal neural plate morphology J:87675
abnormal placenta development J:87675
abnormal placental labyrinth vasculature morphology J:87675
abnormal trophoblast giant cell morphology J:87675
abnormal vasculogenesis J:87675
abnormal visceral yolk sac morphology J:87675
absent placental labyrinth J:87675
decreased embryo size J:87675
decreased trophoblast giant cell number J:87675
delayed chorioallantoic fusion J:87675
dilated dorsal aorta J:87675
dilated vasculature J:87675
embryonic growth retardation J:87675
embryonic lethality during organogenesis, complete penetrance J:87675
enlarged pericardium J:87675
incomplete embryo turning J:87675
increased apoptosis J:87675
increased placenta apoptosis J:87675
intracranial hemorrhage J:87675
pallor J:87675
small ectoplacental cone J:87675
Pnpla6tm1Mvc/Pnpla6tm1Mvc
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal axon morphology J:152759
abnormal corticospinal tract morphology J:152759
abnormal hippocampus morphology J:89288
abnormal lateral corticospinal tract morphology J:152759
abnormal motor coordination/balance J:89288
abnormal neuron morphology J:89288
abnormal phospholipid level J:152759
abnormal thalamus morphology J:89288
abnormal voluntary movement J:152759
decreased body weight J:89288
decreased Purkinje cell number J:89288
neurodegeneration J:89288
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory