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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Crim1
cysteine rich transmembrane BMP regulator 1
MGI:1354756
98 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Crim1em1(IMPC)Wtsi/Crim1+
C57BL/6N-Crim1em1(IMPC)Wtsi/WtsiOrl 		trunk curl J:211773
Crim1em1(IMPC)Wtsi/Crim1em1(IMPC)Wtsi
C57BL/6N-Crim1em1(IMPC)Wtsi/WtsiOrl 		abnormal ductus venosus valve morphology J:239583
abnormal eye morphology J:239583
abnormal hepatic portal vein connection J:239583
abnormal hypoglossal nerve topology J:239583
abnormal Meckel's cartilage morphology J:239583
abnormal Mullerian duct topology J:239583
abnormal rib morphology J:239583
abnormal vertebral arch morphology J:239583
abnormal vertebral artery topology J:239583
abnormal vitelline vein connection J:239583
abnormal vitelline vein topology J:239583
absent connection between subcutaneous lymph vessels and lymph sac J:239583
absent ductus venosus J:239583
absent ductus venosus valve J:239583
absent mandibular nerve J:239583
absent posterior communicating artery J:239583
absent segment of posterior cerebral artery J:239583
anal atresia J:239583
anastomosis between internal carotid artery and basilar artery J:239583
aortic arch coarctation J:239583
blood in lymph vessels J:239583
decreased parotid gland size J:239583
fragmented Meckel's cartilage J:239583
fused dorsal root ganglion J:239583
fusion of vertebral arches J:239583
herniated liver J:239583
lens dislocation J:239583
muscular ventricular septal defect J:239583
perimembraneous ventricular septal defect J:239583
preweaning lethality, complete penetrance J:211773
pulmonary vein hypoplasia J:239583
retrolental blood J:239583
subcutaneous edema J:239583
syndactyly J:239583
telangiectasia J:239583
Crim1Gt(KST264)Byg/Crim1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal glomerular capillary morphology J:147543
dilated glomerular capillary J:147543
glomerulus hemorrhage J:147543
Crim1Gt(KST264)Byg/Crim1+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		dilated renal tubule J:147543
renal interstitial fibrosis J:147543
normal renal/urinary system phenotype J:147543
Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal eye posterior chamber morphology J:117237
abnormal glomerular capillary endothelium morphology J:147543
abnormal glomerular capillary morphology J:147543
abnormal optic cup morphology J:117237
abnormal podocyte foot process morphology J:147543
abnormal podocyte morphology J:147543
abnormal renal glomerulus basement membrane morphology J:147543
cerebral edema J:117237
decreased podocyte number J:147543
dilated glomerular capillary J:147543
fetal bleb J:117237
glomerulus hemorrhage J:147543
hematoma J:117237
increased renal glomerulus basement membrane thickness J:147543
mesangiolysis J:147543
perinatal lethality, complete penetrance J:117237
podocyte foot process effacement J:147543
renal glomerulus hypertrophy J:147543
small kidney J:117237
small lens J:117237
syndactyly J:117237
Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		abnormal basal lamina morphology J:172334
abnormal glomerular capillary endothelium morphology J:147543
abnormal glomerular filtration barrier function J:172334
abnormal kidney corticomedullary boundary morphology J:187026
abnormal kidney pelvis morphology J:187026
abnormal peritubular capillary endothelium morphology J:172334
abnormal peritubular capillary morphology J:172334
abnormal renal filtration rate J:187026
abnormal renal glomerulus morphology J:172334
abnormal renin activity J:172334
absent glomerular endothelium fenestra J:147543
albuminuria J:147543
normal cardiovascular system phenotype J:147543
cortical renal glomerulopathies J:147543
decreased renal glomerular filtration rate J:147543
decreased renal glomerulus basement membrane thickness J:172334
decreased survivor rate J:147543
dilated glomerular capillary J:172334
dilated renal tubule J:147543
glomerulosclerosis J:172334
normal growth/size/body region phenotype J:147543
normal hematopoietic system phenotype J:147543
hydronephrosis J:187026
impaired ureteric peristalsis J:187026
increased glomerular capsule space J:147543
increased kidney apoptosis J:187026
increased vascular permeability J:172334
kidney cortex cyst J:147543, J:187026
kidney inflammation J:172334
kidney papillary atrophy J:187026
kidney papillary hypoplasia J:187026
perinatal lethality, incomplete penetrance J:147543
podocyte foot process effacement J:147543, J:172334
renal glomerulus cyst J:147543, J:172334, J:187026
renal glomerulus hypertrophy J:147543
renal interstitial fibrosis J:147543, J:172334
renal tubular necrosis J:172334
normal renal/urinary system phenotype J:147543, J:172334
short kidney papilla J:187026
small kidney J:187026
Crim1tm1(GFP/cre/ERT2)Pzg/Crim1+
involves: 129S7/SvEvBrd * C57BL/6 		no abnormal phenotype detected J:159099
Crim1tm1.1Dpen/Crim1tm1.1Dpen
B6.129P2(129S7)-Crim1tm1.1Dpen 		postnatal lethality, complete penetrance J:187855
Crim1tm1.1Dpen/Crim1tm1.1Dpen
either: (B6.129P2(129S7)-Crim1tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1) 		abnormal renal glomerulus morphology J:187855
bleb J:187855
edema J:187855
microphthalmia J:187855
renal hypoplasia J:187855
syndactyly J:187855
Crim1tm1.1Dpen/Crim1tm1.1Dpen
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1 		lethality, incomplete penetrance J:187855
Crim1tm1Dpen/Crim1tm1Dpen
B6.129P2-Crim1tm1Dpen 		no abnormal phenotype detected J:187855
Crim1tm1Dpen/Crim1tm1Dpen
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		no abnormal phenotype detected J:187855
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory