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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Socs1
suppressor of cytokine signaling 1
MGI:1354910
83 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Socs1tm1.1(KOMP)Vlcg/Socs1tm1.1(KOMP)Vlcg
C57BL/6N-Socs1tm1.1(KOMP)Vlcg/Tcp 		preweaning lethality, complete penetrance J:211773
Socs1tm1.1Ayr/Socs1tm1.1Ayr
involves: C57BL/6 		abnormal T cell physiology J:226678
decreased effector memory T-helper cell number J:226678
decreased susceptibility to experimental autoimmune encephalomyelitis J:226678
Socs1tm1Ayos/Socs1tm1Ayos
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:132905
Socs1tm1Ayos/Socs1tm1Ayos
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		blepharitis J:167922
conjunctivitis J:167922
dermatitis J:167922
increased regulatory T cell number J:167922
Socs1tm1Ayos/Socs1tm1Ayos
Tg(Lck-cre)1Jtak/0
involves: 129S4/SvJae * C57BL/6 		abnormal CD4-positive T cell differentiation J:132905
abnormal CD4-positive, alpha-beta T cell physiology J:132905
decreased susceptibility to experimental autoimmune encephalomyelitis J:132905
Socs1tm1Ayos/Socs1tm1Ayos
Tg(Tek-cre)1Ywa/0
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased CD4-positive, alpha-beta T cell number J:132905
increased CD8-positive, alpha-beta T cell number J:132905
premature death J:132905
Socs1tm1Jni/Socs1+
Not Specified 		abnormal cytokine level J:91651
abnormal interleukin level J:91651
abnormal liver morphology J:91651
increased hepatoma incidence J:91651
increased susceptibility to xenobiotic induced morbidity/mortality J:91651
Socs1tm1Jni/Socs1tm1Jni
Not Specified 		abnormal cytokine secretion J:57475
abnormal T cell differentiation J:57475
decreased B cell number J:57475
decreased thymocyte number J:57475
postnatal lethality, complete penetrance J:57475
Socs1tm1Kish/Socs1tm1Kish
B6.129P2-Socs1tm1Kish 		abnormal lymphocyte physiology J:69472
decreased body size J:69472
enlarged liver J:69472
increased activated T cell number J:69472
increased NK T cell number J:69472
increased susceptibility to injury J:69472
liver inflammation J:69472
postnatal lethality, complete penetrance J:69472
thymus atrophy J:69472
Socs1tm1Kish/Socs1tm1Kish
involves: 129P2/OlaHsd * C57BL/6J 		abnormal spleen morphology J:51685
abnormal spleen white pulp morphology J:51685
absent thymus corticomedullary boundary J:51685
decreased lymphocyte cell number J:51685
enlarged liver J:51685
postnatal growth retardation J:51685
postnatal lethality, complete penetrance J:51685
Socs1tm1Wehi/Socs1tm1Wehi
involves: 129S1/Sv * C57BL/6 		abnormal follicular B cell morphology J:51281
abnormal inflammatory response J:57474
abnormal lymph node B cell domain morphology J:51281
abnormal macrophage physiology J:57474
abnormal mature B cell morphology J:51281
abnormal Peyer's patch morphology J:51281
abnormal pulmonary alveolus wall morphology J:51281
abnormal spleen white pulp morphology J:57474
decreased B cell number J:51281
decreased body weight J:51281
decreased bone marrow cell number J:57474
decreased eosinophil cell number J:51281
decreased hematocrit J:51281
decreased leukocyte cell number J:57474
decreased lymphocyte cell number J:51281
decreased pre-B cell number J:51281
decreased susceptibility to Togaviridae infection induced morbidity/mortality J:57474
heart inflammation J:51281
normal hematopoietic system phenotype J:57474
hepatic necrosis J:57474
hepatic steatosis J:51281, J:57474
increased inflammatory response J:72528
increased spleen red pulp amount J:51281
liver degeneration J:51281
liver inflammation J:51281
pancreas inflammation J:51281
postnatal growth retardation J:51281
postnatal lethality, complete penetrance J:51281, J:57474, J:72528
small thymus J:51281
thick epidermis J:57474
thrombocytopenia J:51281
thymus cortex atrophy J:51281, J:57474
Socs1tm1Wehi/Socs1tm3Wehi
Tg(Lck-cre)I57Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * ICR 		abnormal CD4-positive, alpha beta T cell morphology J:83009
abnormal CD8-positive, alpha beta T cell morphology J:83009
abnormal T cell activation J:83009
abnormal T cell differentiation J:83009
abnormal T cell subpopulation ratio J:83009
decreased B cell number J:83009
enlarged lymph nodes J:83009
enlarged thymus medulla J:83009
increased CD4-positive, alpha-beta T cell number J:83009
increased CD8-positive, alpha-beta T cell number J:83009
lymph node hyperplasia J:83009
thymus hyperplasia J:83009
Socs1tm2Wehi/Socs1tm2Wehi
C57BL/6-Socs1tm2Wehi 		absent spleen germinal center J:72528
decreased body weight J:72528
extramedullary hematopoiesis J:72528
glomerulonephritis J:72528
increased incidence of corneal inflammation J:72528
increased inflammatory response J:72528
intestinal inflammation J:72528
liver inflammation J:72528
myocarditis J:72528
myositis J:72528
pancreas inflammation J:72528
premature death J:72528
salivary gland inflammation J:72528
skin inflammation J:72528
thymus atrophy J:72528
Socs1tm3.1Wehi/Socs1tm3.1Wehi
C57BL/6-Socs1tm3.1Wehi 		abnormal inflammatory response J:83009
increased circulating interferon-gamma level J:83009
preweaning lethality, incomplete penetrance J:83009
Socs1tm3Wehi/Socs1tm3Wehi
C57BL/6-Socs1tm3Wehi 		no abnormal phenotype detected J:83009
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory