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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
MGI:1354953
47 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Magi2tm1.1Knis/Magi2tm1.1Knis
Not Specified 		abnormal podocyte foot process morphology J:216062
abnormal podocyte slit diaphragm morphology J:216062
anuria J:216062
fused podocyte foot processes J:216062
increased circulating creatinine level J:216062
postnatal lethality, complete penetrance J:216062
Magi2tm1Key/Magi2+
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) 		no abnormal phenotype detected J:213553
Magi2tm1Key/Magi2tm1Key
involves: 129S4/SvJae 		abnormal endoplasmic reticulum morphology J:213553
abnormal glomerular capsule parietal layer morphology J:213553
abnormal glomerular filtration barrier function J:213553
abnormal podocyte morphology J:213553
abnormal podocyte slit diaphragm morphology J:213553
absent glomerular endothelium fenestra J:213553
absent podocytes J:213553
albuminuria J:213553
cortical renal glomerulopathies J:213553
expanded mesangial matrix J:213553
glomerular crescent J:213553
glomerulosclerosis J:213553
increased blood urea nitrogen level J:213553
increased circulating creatinine level J:213553
increased urine protein level J:213553
kidney failure J:213553
normal nervous system phenotype J:213553
podocyte foot process effacement J:213553
podocyte hypertrophy J:213553
podocyte microvillus transformation J:213553
postnatal growth retardation J:213553
premature death J:213553
renal cast J:213553
renal interstitial fibrosis J:213553
renal tubule atrophy J:213553
tubulointerstitial nephritis J:213553
Magi2tm1Key/Magi2tm1Key
involves: 129S4/SvJae * C57BL/6 		increased blood urea nitrogen level J:213553
increased circulating creatinine level J:213553
increased urine protein level J:213553
premature death J:213553
Magi2tm1Yhat/Magi2tm1Yhat
involves: 129S/SvEv * C57BL/6 * DBA/2 		abnormal neuron morphology J:122354
neonatal lethality, complete penetrance J:122354
Tg(Camk2a-Magi2)1Shlee/?
C57BL/6J-Tg(Camk2a-Magi2)1Shlee 		abnormal brain interneuron morphology J:218971
abnormal dendritic spine morphology J:218971
abnormal excitatory postsynaptic potential J:218971
abnormal nest building behavior J:218971
abnormal social investigation J:218971
abnormal social/conspecific interaction behavior J:218971
abnormal spatial working memory J:218971
abnormal sweet taste sensitivity J:218971
anhedonia J:218971
decreased prepulse inhibition J:218971
enlarged lateral ventricles J:218971
increased anxiety-related response J:218971
increased locomotor activity J:218971
reduced long-term potentiation J:218971
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory