Copb2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Copb2
COPI coat complex subunit beta 2
MGI:1354962

18 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Copb2^em1(IMPC)Bay/Copb2⁺ C57BL/6N-Copb2^em1(IMPC)Bay/Bay	abnormal retina vasculature morphology	J:211773
	decreased grip strength	J:211773
	decreased locomotor activity	J:211773
	decreased total body fat amount	J:211773
	increased lean body mass	J:211773
Copb2^em1(IMPC)Bay/Copb2^em1(IMPC)Bay C57BL/6N-Copb2^em1(IMPC)Bay/Bay	prenatal lethality	J:211773
	preweaning lethality, complete penetrance	J:211773
Copb2^em1Rstot/Copb2^em1Rstot involves: C57BL/6J * DBA/2	embryonic lethality between implantation and placentation	J:252710
Copb2^em1Rstot/Copb2^em2Rstot involves: C57BL/6 * C57BL/6J * CD-1 * DBA/2	abnormal cerebral cortex morphology	J:252710
	abnormal neuron proliferation	J:252710
	abnormal suckling behavior	J:252710
	decreased birth body size	J:252710
	decreased brain weight	J:252710
	increased neuron apoptosis	J:252710
	increased neuronal precursor proliferation	J:252710
	preweaning lethality, incomplete penetrance	J:252710
Copb2^em2Rstot/Copb2^em2Rstot involves: C57BL/6 * CD-1 * DBA/2	no abnormal phenotype detected	J:252710
Copb2^em3Rstot/Copb2^em3Rstot involves: C57BL/6 * CD-1 * DBA/2	embryonic lethality prior to tooth bud stage, complete penetrance	J:252710

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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