Prkn Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkn
parkin RBR E3 ubiquitin protein ligase
MGI:1355296

48 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkn^tm1Ccs/Prkn^tm1Ccs involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal dopamine level	J:127250
	abnormal neuron morphology	J:127707
	abnormal spatial learning	J:127250
	normal behavior/neurological phenotype	J:127250
	brain vacuoles	J:127707
	decreased exploration in new environment	J:127250
	impaired behavioral response to xenobiotic	J:127250
	increased anxiety-related response	J:127250
	increased thigmotaxis	J:127250
	normal nervous system phenotype	J:127250, J:127707
Prkn^tm1Ccs/Prkn^tm1Ccs involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal CNS glial cell morphology	J:168847
	abnormal mitochondrial morphology	J:168847
Prkn^tm1Roo/Prkn^tm1Roo either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)	abnormal stationary movement	J:85561
	abnormal synaptic transmission	J:85561
	decreased body weight	J:85561
	decreased core body temperature	J:85561
	decreased exploration in new environment	J:85561
	increased dopamine level	J:85561
	normal muscle phenotype	J:85561
	normal nervous system phenotype	J:85561
Prkn^tm1Roo/Prkn^tm1Roo involves: 129S2/SvPas	abnormal locomotor activation	J:125148
	abnormal posture	J:125148
	abnormal respiratory function	J:125148
	abnormal tail movements	J:125148
	alopecia	J:125148
	decreased substantia nigra size	J:125148
	hippocampal neuron degeneration	J:125148
	increased neuron apoptosis	J:125148
	kyphosis	J:125148
	loss of dopaminergic neurons	J:125148
	neuron degeneration	J:125148
	premature death	J:125148
	short stride length	J:125148
	tau protein deposits	J:125148
Prkn^tm1Rpa/Prkn^tm1Rpa involves: 129S4/SvJaeSor * C57BL/6	normal behavior/neurological phenotype	J:95204
	normal homeostasis/metabolism phenotype	J:95204
	normal nervous system phenotype	J:95204
Prkn^tm1Shn/Prkn^tm1Shn B6.129S4-Prkn^tm1Shn/J	abnormal autophagy	J:193741
	abnormal mitochondrial morphology	J:193741
	abnormal mitochondrial physiology	J:193741
	abnormal mitophagy	J:193741
	abnormal response to cardiac infarction	J:193741
	decreased body size	J:193741
	decreased mitochondrial size	J:193741
	impaired coordination	J:202221
	increased sensitivity to induced cell death	J:193741, J:194987
	increased susceptibility to induced morbidity/mortality	J:193741
Prkn^tm1Shn/Prkn^tm1Shn involves: 129S4/SvJae	abnormal nervous system electrophysiology	J:86377
	impaired coordination	J:86377
	increased dopamine level	J:86377
Prkn^tm1Tmd/Prkn^tm1Tmd involves: C57BL/6	abnormal locus ceruleus morphology	J:91487
	decreased noradrenaline level	J:91487
	decreased startle reflex	J:91487
Prkn^tm1Ykt/Prkn^tm1Ykt involves: 129P2/OlaHsd * C57BL/6	abnormal substantia nigra pars compacta morphology	J:117737
	decreased body weight	J:117737
	increased dopamine level	J:117737
Prkn^tm2Tmd/Prkn^tm2Tmd Not Specified	decreased dopaminergic neuron number	J:171058

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24