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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il22
interleukin 22
MGI:1355307
35 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il22tm1.1Lex/Il22tm1.1Lex
involves: 129S5/SvEvBrd 		abnormal circulating cytokine level J:179011
abnormal colon morphology J:161073
abnormal large intestine crypts of Lieberkuhn morphology J:161073
colitis J:161073
decreased body weight J:161073
decreased circulating interleukin-1 alpha level J:179011
decreased circulating interleukin-12 level J:179011
decreased circulating interleukin-12b level J:179011
decreased circulating tumor necrosis factor level J:179011
increased circulating interleukin-17 level J:179011
increased susceptibility to bacterial infection induced morbidity/mortality J:161073
increased susceptibility to fungal infection J:179011
lung inflammation J:179011
multifocal hepatic necrosis J:161073
Il22tm1.1Lex/Il22tm1.1Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal cytokine secretion J:118261
acanthosis J:118261
ear inflammation J:118261
mixed cellular infiltration to dermis J:118261
thick dermal layer J:118261
Il22tm1Flv/Il22+
B6.Cg-Il22tm1Flv 		increased physiological sensitivity to xenobiotic J:126103
increased susceptibility to endotoxin shock J:126103
Il22tm1Flv/Il22tm1Flv
B6.Cg-Il22tm1Flv 		increased circulating alanine transaminase level J:126103
increased circulating aspartate transaminase level J:126103
increased physiological sensitivity to xenobiotic J:126103
increased susceptibility to endotoxin shock J:126103
liver inflammation J:126103
Il22tm1Flv/Il22tm1Flv
involves: 129/Sv * C57BL/6 		increased incidence of tumors by chemical induction J:189217
increased susceptibility to induced colitis J:189217
Il22tm1Jcrd/Il22tm1Jcrd
B6.Cg-Il22tm1Jcrd 		normal immune system phenotype J:155038
Il22tm1Jcrd/Il22tm1Jcrd
Not Specified 		decreased neutrophil cell number J:193548
decreased physiological sensitivity to xenobiotic J:193548
increased interleukin-17 secretion J:193548
Il22tm1Vlcg/Il22tm1Vlcg
Not Specified 		abnormal skin morphology J:197959
abnormal wound healing J:197959
delayed wound healing J:197959
Tg(Fabp4-Il22)#Ychn/0
involves: ICR 		normal homeostasis/metabolism phenotype J:176141
increased liposarcoma incidence J:176141
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory