Tnfsf14 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
MGI:1355317

57 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Lck-Tnfsf14)24Yxf/? C57BL/6-Tg(Lck-Tnfsf14)24Yxf	abnormal complement protein level	J:128976
	abnormal glomerular mesangium morphology	J:128976
	abnormal inflammatory response	J:128976
	abnormal intestinal epithelium morphology	J:128976
	abnormal intestine morphology	J:128976
	abnormal liver morphology	J:120962
	abnormal lymph node cell ratio	J:129951
	abnormal renal glomerulus morphology	J:128976
	abnormal T cell physiology	J:120962, J:129951
	colitis	J:129951
	extramedullary hematopoiesis	J:129951
	glomerulonephritis	J:129951
	glomerulosclerosis	J:128976
	hematuria	J:128976
	increased anti-double stranded DNA antibody level	J:129951
	increased anti-nuclear antigen antibody level	J:128976
	increased autoantibody level	J:129951
	increased circulating cholesterol level	J:120962
	increased circulating triglyceride level	J:120962
	increased enterocyte apoptosis	J:128976
	increased IgA level	J:128976
	increased IgG level	J:128976
	increased spleen weight	J:129951
	increased T cell proliferation	J:129951
	increased urine protein level	J:128976
	intestinal inflammation	J:128976
	liver inflammation	J:129951
	lung inflammation	J:129951
	lymph node hyperplasia	J:129951
	myositis	J:129951
	renal glomerular immunoglobulin deposits	J:129951
	small intestinal inflammation	J:120962
	spleen hyperplasia	J:129951
	spontaneous skin ulceration	J:129951
Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy involves: 129S1/Sv * 129X1/SvJ	abnormal cytotoxic T cell physiology	J:84366
	abnormal T cell activation	J:84366
	decreased T cell proliferation	J:84366
	normal immune system phenotype	J:84366
Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf B6.129P2-Tnfsf14^tm1Kpf	abnormal chondrocyte morphology	J:294030
	abnormal compact bone morphology	J:294030
	abnormal osteoclast differentiation	J:294030
	abnormal spine curvature	J:294030
	abnormal thoracic vertebrae morphology	J:294030
	abnormal trabecular bone morphology	J:294030
	decreased trabecular bone volume	J:294030
	increased bone trabecular spacing	J:294030
Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf involves: 129P2/OlaHsd	abnormal gamma-delta T cell morphology	J:169863
Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf involves: 129P2/OlaHsd * C57BL/6	abnormal T cell subpopulation ratio	J:77250
	decreased cytotoxic T cell cytolysis	J:77250
	decreased interferon-gamma secretion	J:77250
	decreased interleukin-2 secretion	J:77250
	decreased interleukin-4 secretion	J:77250
	decreased interleukin-10 secretion	J:77250
	decreased splenocyte proliferation	J:77250
	decreased T cell proliferation	J:77250
Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc B6.129X1-Tnfsf14^tm1Lpc	normal immune system phenotype	J:158663
Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc involves: 129X1/SvJ * C57BL/6	abnormal cytotoxic T cell physiology	J:76414
	decreased cytotoxic T cell cytolysis	J:76414
	decreased inflammatory response	J:107803
	decreased interferon-gamma secretion	J:76414
	decreased tumor necrosis factor secretion	J:76414
Tnfsf14^tm1Wwh/Tnfsf14^tm1Wwh involves: 129 * C57BL/6	increased length of allograft survival	J:75705

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24