Chek2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chek2
checkpoint kinase 2
MGI:1355321

6 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chek2^{tm1b(EUCOMM)Hmgu}/Chek2^{tm1b(EUCOMM)Hmgu} B6N(Cg)-Chek2^{tm1b(EUCOMM)Hmgu}/J	increased circulating sodium level	J:211773
Chek2^tm1Mak/Chek2^tm1Mak involves: 129P2/OlaHsd	decreased cellular sensitivity to ionizing radiation	J:126186
Chek2^tm1Mak/Chek2^tm1Mak involves: 129P2/OlaHsd * C57BL/6	abnormal cell cycle checkpoint function	J:78491
	decreased cellular sensitivity to gamma-irradiation	J:78491
	increased incidence of tumors by chemical induction	J:78491
Chek2^tm1Nmt/Chek2^tm1Nmt involves: 129P2/OlaHsd * C57BL/6J	decreased cellular sensitivity to ionizing radiation	J:88888
Chek2^tm1Nmt/Chek2^tm1Nmt involves: 129P2/OlaHsd * C57BL/6J	decreased mortality induced by ionizing radiation	J:88888

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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