Chek2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chek2
checkpoint kinase 2
MGI:1355321

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Lck-cre)548Jxm/? involves: 129P2/OlaHsd * C57BL/6 * CBA	normal cellular phenotype	J:90512
	chromosomal instability	J:90512
	normal immune system phenotype	J:90512
	increased T cell derived lymphoma incidence	J:90512
Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/? involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	increased mammary adenocarcinoma incidence	J:90512
Cep63^{Gt(EUCE0251h11)Hmgu}/Cep63^{Gt(EUCE0251h11)Hmgu} Chek2^tm1Mak/Chek2^tm1Mak involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	thin cerebral cortex	J:224364
Chek2^{tm1b(EUCOMM)Hmgu}/Chek2^{tm1b(EUCOMM)Hmgu} Prdm9^tm1Ymat/Prdm9^tm1Ymat B6.Cg-Chek2^{tm1b(EUCOMM)Hmgu} Prdm9^tm1Ymat	abnormal chiasmata formation	J:299008
	abnormal female meiosis	J:299008
	abnormal female meiosis I arrest	J:299008
	abnormal miscarriage rate	J:299008
	decreased oocyte number	J:299008
	reduced female fertility	J:299008
Chek2^tm1Mak/Chek2⁺ Rad50^tm2Jpt/Rad50^tm2Jpt involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	abnormal pro-B cell morphology	J:103922
	anemia	J:103922
	decreased double-negative T cell number	J:103922
	decreased macrophage cell number	J:103922
	premature death	J:103922
Chek2^tm1Mak/Chek2^tm1Mak Rad50^tm2Jpt/Rad50^tm2Jpt involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	normal hematopoietic system phenotype	J:103922
	increased lymphoma incidence	J:103922
	premature death	J:103922
Chek2^tm1Mak/Chek2^tm1Mak Swsap1^em1Mjn/Swsap1^em1Mjn involves: 129P2/OlaHsd * C57BL/6J * CBA/J	abnormal chromosomal synapsis	J:268570
	abnormal seminiferous tubule morphology	J:268570
	decreased litter size	J:268570
	decreased oocyte number	J:268570
	decreased primordial ovarian follicle number	J:268570
	decreased testis weight	J:268570
	impaired embryo implantation	J:268570
	male infertility	J:268570
	oligozoospermia	J:268570
	reduced female fertility	J:268570
	normal reproductive system phenotype	J:268570
Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn involves: 129P2/OlaHsd * C57BL/6J * CBA/J	abnormal seminiferous tubule morphology	J:268570
	decreased litter size	J:268570
	decreased primordial ovarian follicle number	J:268570
	decreased testis weight	J:268570
	male infertility	J:268570
	oligozoospermia	J:268570
	reduced female fertility	J:268570
	normal reproductive system phenotype	J:268570
Chek2^tm1Pjs/Chek2^tm1Pjs involves: 129/Sv * Black Swiss * FVB/N	abnormal cell cycle	J:118262
	abnormal cell physiology	J:118262
	polyploidy	J:118262

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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