Chek2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chek2
checkpoint kinase 2
MGI:1355321

31 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Lck-cre)548Jxm/? involves: 129P2/OlaHsd * C57BL/6 * CBA	normal cellular phenotype	J:90512
	chromosomal instability	J:90512
	normal immune system phenotype	J:90512
	increased T cell derived lymphoma incidence	J:90512
Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/? involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	increased mammary adenocarcinoma incidence	J:90512
Cep63^{Gt(EUCE0251h11)Hmgu}/Cep63^{Gt(EUCE0251h11)Hmgu} Chek2^tm1Mak/Chek2^tm1Mak involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	thin cerebral cortex	J:224364
Chek2^{tm1b(EUCOMM)Hmgu}/Chek2^{tm1b(EUCOMM)Hmgu} Prdm9^tm1Ymat/Prdm9^tm1Ymat B6.Cg-Chek2^{tm1b(EUCOMM)Hmgu} Prdm9^tm1Ymat	abnormal chiasmata formation	J:299008
	abnormal female meiosis	J:299008
	abnormal female meiosis I arrest	J:299008
	abnormal miscarriage rate	J:299008
	decreased oocyte number	J:299008
	reduced female fertility	J:299008
Chek2^tm1Mak/Chek2⁺ Rad50^tm2Jpt/Rad50^tm2Jpt involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	abnormal pro-B cell morphology	J:103922
	anemia	J:103922
	decreased double-negative T cell number	J:103922
	decreased macrophage cell number	J:103922
	premature death	J:103922
Chek2^tm1Mak/Chek2^tm1Mak Rad50^tm2Jpt/Rad50^tm2Jpt involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	normal hematopoietic system phenotype	J:103922
	increased lymphoma incidence	J:103922
	premature death	J:103922
Chek2^tm1Mak/Chek2^tm1Mak Swsap1^em1Mjn/Swsap1^em1Mjn involves: 129P2/OlaHsd * C57BL/6J * CBA/J	abnormal chromosomal synapsis	J:268570
	abnormal seminiferous tubule morphology	J:268570
	decreased litter size	J:268570
	decreased oocyte number	J:268570
	decreased primordial ovarian follicle number	J:268570
	decreased testis weight	J:268570
	impaired embryo implantation	J:268570
	male infertility	J:268570
	oligozoospermia	J:268570
	reduced female fertility	J:268570
	normal reproductive system phenotype	J:268570
Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn involves: 129P2/OlaHsd * C57BL/6J * CBA/J	abnormal seminiferous tubule morphology	J:268570
	decreased litter size	J:268570
	decreased primordial ovarian follicle number	J:268570
	decreased testis weight	J:268570
	male infertility	J:268570
	oligozoospermia	J:268570
	reduced female fertility	J:268570
	normal reproductive system phenotype	J:268570
Chek2^tm1Pjs/Chek2^tm1Pjs involves: 129/Sv * Black Swiss * FVB/N	abnormal cell cycle	J:118262
	abnormal cell physiology	J:118262
	polyploidy	J:118262

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24